Species differences in the pattern of eicosanoids produced by inflamed and non-inflamed tissue

F.J. Zijlstra; A.P.M. van Dijk; I. M. Garrelds; R.J.T. Ouwendijk; J.H.P. Wilson

doi:10.1007/BF01991027

Species differences in the pattern of eicosanoids produced by inflamed and non-inflamed tissue

F.J. Zijlstra^*
, A.P.M. van Dijk
, I. M. Garrelds
, R.J.T. Ouwendijk
, J.H.P. Wilson

^*Corresponding author for this work

Ikazia Hospital

Research output: Contribution to journal › Article › Academic › peer-review

13 Citations (Scopus)

Abstract

The synthesis of¹⁴C labelled arachidonic acid metabolites was measured in colonic tissues obtained from mice, rats, guinea pigs, rabbits, piglets and in colonic biopsies from humans during colonoscopy. The main eicosanoids formed after stimulation with calcium ionophore A23187 were: in humans, 15-hydroxy-eicosatetraenoic acid (15-HETE); in mice, 12-HETE; in rats, 12-HETE, 12-hydroxy-5,8,10-heptadecatrienoic acid (HHT) and 6-keto-prostaglandine F_1α (6kPGF_1α); in guinea pigs, PGD₂; in rabbits, 6kPGF_1α, PGE₂ and 15-HETE; and in pigs PGE₂ and 12-HETE. In inflamed 15-HETE production was increased in man, HHT and 12-HETE production in rats and overall eicosanoid production in mice.

Original language	English
Pages (from-to)	C73-C75
Journal	Agents and Actions
Volume	36
Issue number	1 Supplement
DOIs	https://doi.org/10.1007/BF01991027
Publication status	Published - Mar 1992

Bibliographical note

Experimental Aspects of Gastrointestinal Inflammation New Approaches to Therapy of Gastrointestinal Inflammation General Inflammation Research Topics ;
3rd Meeting on Side Effects of Anti-Inflammatory Drugs and 13th European Workshop on Inflammation Verona, Italy

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10.1007/BF01991027

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@article{107b530031194fabb09f561c97ef0d0b,

title = "Species differences in the pattern of eicosanoids produced by inflamed and non-inflamed tissue",

abstract = "The synthesis of14C labelled arachidonic acid metabolites was measured in colonic tissues obtained from mice, rats, guinea pigs, rabbits, piglets and in colonic biopsies from humans during colonoscopy. The main eicosanoids formed after stimulation with calcium ionophore A23187 were: in humans, 15-hydroxy-eicosatetraenoic acid (15-HETE); in mice, 12-HETE; in rats, 12-HETE, 12-hydroxy-5,8,10-heptadecatrienoic acid (HHT) and 6-keto-prostaglandine F1α (6kPGF1α); in guinea pigs, PGD2; in rabbits, 6kPGF1α, PGE2 and 15-HETE; and in pigs PGE2 and 12-HETE. In inflamed 15-HETE production was increased in man, HHT and 12-HETE production in rats and overall eicosanoid production in mice.",

author = "F.J. Zijlstra and \{van Dijk\}, A.P.M. and Garrelds, \{I. M.\} and R.J.T. Ouwendijk and J.H.P. Wilson",

note = "Experimental Aspects of Gastrointestinal Inflammation New Approaches to Therapy of Gastrointestinal Inflammation General Inflammation Research Topics ; 3rd Meeting on Side Effects of Anti-Inflammatory Drugs and 13th European Workshop on Inflammation Verona, Italy",

year = "1992",

month = mar,

doi = "10.1007/BF01991027",

language = "English",

volume = "36",

pages = "C73--C75",

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TY - JOUR

T1 - Species differences in the pattern of eicosanoids produced by inflamed and non-inflamed tissue

AU - Zijlstra, F.J.

AU - van Dijk, A.P.M.

AU - Garrelds, I. M.

AU - Ouwendijk, R.J.T.

AU - Wilson, J.H.P.

N1 - Experimental Aspects of Gastrointestinal Inflammation New Approaches to Therapy of Gastrointestinal Inflammation General Inflammation Research Topics ; 3rd Meeting on Side Effects of Anti-Inflammatory Drugs and 13th European Workshop on Inflammation Verona, Italy

PY - 1992/3

Y1 - 1992/3

N2 - The synthesis of14C labelled arachidonic acid metabolites was measured in colonic tissues obtained from mice, rats, guinea pigs, rabbits, piglets and in colonic biopsies from humans during colonoscopy. The main eicosanoids formed after stimulation with calcium ionophore A23187 were: in humans, 15-hydroxy-eicosatetraenoic acid (15-HETE); in mice, 12-HETE; in rats, 12-HETE, 12-hydroxy-5,8,10-heptadecatrienoic acid (HHT) and 6-keto-prostaglandine F1α (6kPGF1α); in guinea pigs, PGD2; in rabbits, 6kPGF1α, PGE2 and 15-HETE; and in pigs PGE2 and 12-HETE. In inflamed 15-HETE production was increased in man, HHT and 12-HETE production in rats and overall eicosanoid production in mice.

AB - The synthesis of14C labelled arachidonic acid metabolites was measured in colonic tissues obtained from mice, rats, guinea pigs, rabbits, piglets and in colonic biopsies from humans during colonoscopy. The main eicosanoids formed after stimulation with calcium ionophore A23187 were: in humans, 15-hydroxy-eicosatetraenoic acid (15-HETE); in mice, 12-HETE; in rats, 12-HETE, 12-hydroxy-5,8,10-heptadecatrienoic acid (HHT) and 6-keto-prostaglandine F1α (6kPGF1α); in guinea pigs, PGD2; in rabbits, 6kPGF1α, PGE2 and 15-HETE; and in pigs PGE2 and 12-HETE. In inflamed 15-HETE production was increased in man, HHT and 12-HETE production in rats and overall eicosanoid production in mice.

UR - https://www.scopus.com/pages/publications/0026553447

U2 - 10.1007/BF01991027

DO - 10.1007/BF01991027

M3 - Article

C2 - 1442338

AN - SCOPUS:0026553447

SN - 0065-4299

VL - 36

SP - C73-C75

JO - Agents and Actions

JF - Agents and Actions

IS - 1 Supplement

ER -

Species differences in the pattern of eicosanoids produced by inflamed and non-inflamed tissue

Abstract

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