Speckle tracking echocardiography in fetuses diagnosed with congenital diaphragmatic hernia

Philip DeKoninck; Jan D'hooge; Tim Van Mieghem; Jute Richter; Jan Deprest

doi:10.1002/pd.4461

Speckle tracking echocardiography in fetuses diagnosed with congenital diaphragmatic hernia

Philip DeKoninck, Jan D'hooge, Tim Van Mieghem, Jute Richter, Jan Deprest^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

20 Citations (Scopus)

Abstract

OBJECTIVE: The aim of this study is to evaluate cardiac function in fetuses with congenital diaphragmatic hernia (CDH) using speckle tracking.

METHOD: Case-control study assessed cardiac contractility in consecutive fetuses with CDH. Controls were anatomically normal fetuses, adjusted for gestational age. Speckle tracking software calculated ventricular peak longitudinal velocity, displacement and strain. Pulmonary hypoplasia was assessed using observed/expected lung-to-head ratio (O/E LHR).

RESULTS: Thirty-eight fetuses with CDH (29 left and nine right) were evaluated at a mean gestational age of 26.9 ± 2.5 weeks. In six fetuses, the acquired images were of insufficient quality (feasibility 83%). Velocity and displacement showed regional differences, as well as significant differences between the ventricular walls, similar to control fetuses. Strain measurements also demonstrated regional differences yet less uniformly arranged. In left CDH, we observed increased strain values in the left ventricle compared with controls (-18.7 ± 7.2 vs -15.1 ± 4.9). There was no correlation between strain values in the left ventricle and O/E LHR. In fetuses with right CDH, deformation analysis was not different from controls.

CONCLUSIONS: In fetuses with CDH, no cardiac dysfunction could be detected despite the often concurrent hypoplasia of ipsilateral cardiac structures. In fetuses with left CDH, the decrease in ventricular size coincides with increased strain values in the free left ventricular wall.

Original language	English
Pages (from-to)	1262-1267
Number of pages	6
Journal	Prenatal Diagnosis
Volume	34
Issue number	13
DOIs	https://doi.org/10.1002/pd.4461
Publication status	Published - Dec 2014
Externally published	Yes

Bibliographical note

Funding sources:
This work has been supported by the Fonds voor Wetenschappelijk Onderzoek Vlaanderen (1.8.012.07.N.02; J. D. P.), the Instituut voor
Wetenschap en Technologie (IWT/070715), the European Commission (Industria-Academia Partnership via www.endovv.com; PIAP-GA-2009-251356; P. D. K.
and J. R.) and the Klinische onderzoeks- en opleidingsraad fonds of the University Hospitals Leuven (T. V. M.).
Conflicts of interest: None declared

© 2014 John Wiley & Sons, Ltd.

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@article{85f89cdd37654430a1bd240c25b18478,

title = "Speckle tracking echocardiography in fetuses diagnosed with congenital diaphragmatic hernia",

abstract = "OBJECTIVE: The aim of this study is to evaluate cardiac function in fetuses with congenital diaphragmatic hernia (CDH) using speckle tracking.METHOD: Case-control study assessed cardiac contractility in consecutive fetuses with CDH. Controls were anatomically normal fetuses, adjusted for gestational age. Speckle tracking software calculated ventricular peak longitudinal velocity, displacement and strain. Pulmonary hypoplasia was assessed using observed/expected lung-to-head ratio (O/E LHR).RESULTS: Thirty-eight fetuses with CDH (29 left and nine right) were evaluated at a mean gestational age of 26.9 ± 2.5 weeks. In six fetuses, the acquired images were of insufficient quality (feasibility 83%). Velocity and displacement showed regional differences, as well as significant differences between the ventricular walls, similar to control fetuses. Strain measurements also demonstrated regional differences yet less uniformly arranged. In left CDH, we observed increased strain values in the left ventricle compared with controls (-18.7 ± 7.2 vs -15.1 ± 4.9). There was no correlation between strain values in the left ventricle and O/E LHR. In fetuses with right CDH, deformation analysis was not different from controls.CONCLUSIONS: In fetuses with CDH, no cardiac dysfunction could be detected despite the often concurrent hypoplasia of ipsilateral cardiac structures. In fetuses with left CDH, the decrease in ventricular size coincides with increased strain values in the free left ventricular wall.",

author = "Philip DeKoninck and Jan D'hooge and {Van Mieghem}, Tim and Jute Richter and Jan Deprest",

note = "Funding sources: This work has been supported by the Fonds voor Wetenschappelijk Onderzoek Vlaanderen (1.8.012.07.N.02; J. D. P.), the Instituut voor Wetenschap en Technologie (IWT/070715), the European Commission (Industria-Academia Partnership via www.endovv.com; PIAP-GA-2009-251356; P. D. K. and J. R.) and the Klinische onderzoeks- en opleidingsraad fonds of the University Hospitals Leuven (T. V. M.). Conflicts of interest: None declared {\textcopyright} 2014 John Wiley & Sons, Ltd.",

year = "2014",

month = dec,

doi = "10.1002/pd.4461",

language = "English",

volume = "34",

pages = "1262--1267",

journal = "Prenatal Diagnosis",

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T1 - Speckle tracking echocardiography in fetuses diagnosed with congenital diaphragmatic hernia

AU - DeKoninck, Philip

AU - D'hooge, Jan

AU - Van Mieghem, Tim

AU - Richter, Jute

AU - Deprest, Jan

N1 - Funding sources: This work has been supported by the Fonds voor Wetenschappelijk Onderzoek Vlaanderen (1.8.012.07.N.02; J. D. P.), the Instituut voor Wetenschap en Technologie (IWT/070715), the European Commission (Industria-Academia Partnership via www.endovv.com; PIAP-GA-2009-251356; P. D. K. and J. R.) and the Klinische onderzoeks- en opleidingsraad fonds of the University Hospitals Leuven (T. V. M.). Conflicts of interest: None declared © 2014 John Wiley & Sons, Ltd.

PY - 2014/12

Y1 - 2014/12

N2 - OBJECTIVE: The aim of this study is to evaluate cardiac function in fetuses with congenital diaphragmatic hernia (CDH) using speckle tracking.METHOD: Case-control study assessed cardiac contractility in consecutive fetuses with CDH. Controls were anatomically normal fetuses, adjusted for gestational age. Speckle tracking software calculated ventricular peak longitudinal velocity, displacement and strain. Pulmonary hypoplasia was assessed using observed/expected lung-to-head ratio (O/E LHR).RESULTS: Thirty-eight fetuses with CDH (29 left and nine right) were evaluated at a mean gestational age of 26.9 ± 2.5 weeks. In six fetuses, the acquired images were of insufficient quality (feasibility 83%). Velocity and displacement showed regional differences, as well as significant differences between the ventricular walls, similar to control fetuses. Strain measurements also demonstrated regional differences yet less uniformly arranged. In left CDH, we observed increased strain values in the left ventricle compared with controls (-18.7 ± 7.2 vs -15.1 ± 4.9). There was no correlation between strain values in the left ventricle and O/E LHR. In fetuses with right CDH, deformation analysis was not different from controls.CONCLUSIONS: In fetuses with CDH, no cardiac dysfunction could be detected despite the often concurrent hypoplasia of ipsilateral cardiac structures. In fetuses with left CDH, the decrease in ventricular size coincides with increased strain values in the free left ventricular wall.

AB - OBJECTIVE: The aim of this study is to evaluate cardiac function in fetuses with congenital diaphragmatic hernia (CDH) using speckle tracking.METHOD: Case-control study assessed cardiac contractility in consecutive fetuses with CDH. Controls were anatomically normal fetuses, adjusted for gestational age. Speckle tracking software calculated ventricular peak longitudinal velocity, displacement and strain. Pulmonary hypoplasia was assessed using observed/expected lung-to-head ratio (O/E LHR).RESULTS: Thirty-eight fetuses with CDH (29 left and nine right) were evaluated at a mean gestational age of 26.9 ± 2.5 weeks. In six fetuses, the acquired images were of insufficient quality (feasibility 83%). Velocity and displacement showed regional differences, as well as significant differences between the ventricular walls, similar to control fetuses. Strain measurements also demonstrated regional differences yet less uniformly arranged. In left CDH, we observed increased strain values in the left ventricle compared with controls (-18.7 ± 7.2 vs -15.1 ± 4.9). There was no correlation between strain values in the left ventricle and O/E LHR. In fetuses with right CDH, deformation analysis was not different from controls.CONCLUSIONS: In fetuses with CDH, no cardiac dysfunction could be detected despite the often concurrent hypoplasia of ipsilateral cardiac structures. In fetuses with left CDH, the decrease in ventricular size coincides with increased strain values in the free left ventricular wall.

U2 - 10.1002/pd.4461

DO - 10.1002/pd.4461

M3 - Article

C2 - 25043615

SN - 0197-3851

VL - 34

SP - 1262

EP - 1267

JO - Prenatal Diagnosis

JF - Prenatal Diagnosis

IS - 13

ER -

Speckle tracking echocardiography in fetuses diagnosed with congenital diaphragmatic hernia

Abstract

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