Statin use is associated with reduced incidence and progression of knee osteoarthritis in the Rotterdam study

Stefan Clockaerts, Gerjo van Osch, Yvonne Jenniskens, Jan Verhaar, F Van Glabbeek, Joyce van Meurs, Hanneke Kerkhof, Bert Hofman, Bruno Stricker, Sita Bierma - Zeinstra

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Abstract

Background Osteoarthritis is the most frequent chronic joint disease causing pain and disability. Besides biomechanical mechanisms, the pathogenesis of osteoarthritis may involve inflammation, vascular alterations and dysregulation of lipid metabolism. As statins are able to modulate many of these processes, this study examines whether statin use is associated with a decreased incidence and/or progression of osteoarthritis. Methods Participants in a prospective population-based cohort study aged 55 years and older (n=2921) were included. x-Rays of the knee/hip were obtained at baseline and after on average 6.5 years, and scored using the Kellgren and Lawrence score for osteoarthritis. Any increase in score was defined as overall progression (incidence and progression). Data on covariables were collected at baseline. Information on statin use during follow-up was obtained from computerised pharmacy databases. The ov Results Overall progression of knee and hip osteoarthritis occurred in 6.9% and 4.7% of cases, respectively. The adjusted OR for overall progression of knee osteoarthritis in statin users was 0.43 (95% CI 0.25 to 0.77, p=0.01). The use of statins was not associated with overall progression of hip osteoarthritis. Conclusions Statin use is associated with more than a 50% reduction in overall progression of osteoarthritis of the knee, but not of the hip.
Original languageUndefined/Unknown
Pages (from-to)642-647
Number of pages6
JournalAnnals of the Rheumatic Diseases
Volume71
Issue number5
DOIs
Publication statusPublished - 2012

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