TY - JOUR
T1 - STrengthening the REporting of Genetic Association studies (STREGA)-an extension of the strengthening the reporting, of observational studies in epidemiology (STROBE) statement
AU - Little, J
AU - Higgins, JPT
AU - Ioannidis, JPA
AU - Moher, D
AU - Gagnon, F
AU - von Elm, E
AU - Khoury, MJ
AU - Cohen, B
AU - Davey-Smith, G
AU - Grimshaw, J
AU - Scheet, P
AU - Gwinn, M
AU - Williamson, RE
AU - Zou, GY
AU - Hutchings, K
AU - Johnson, CY
AU - Tait, V
AU - Wiens, M
AU - Golding, J
AU - Duijn, Cornelia
AU - McLaughlin, J
AU - Paterson, A
AU - Wells, G
AU - Fortier, I
AU - Freedman, M
AU - Zecevic, M
AU - King, R
AU - Infante-Rivard, C
AU - Stewart, AF
AU - Birkett, N
PY - 2009
Y1 - 2009
N2 - Making sense of rapidly evolving evidence on genetic associations is crucial to making genuine advances in human genomics and the eventual integration of this information in the practice of medicine and public health. Assessment of the strengths and weaknesses of this evidence, and hence, the ability to synthesize it, has been limited by inadequate reporting Of results. The STrengthening the REporting of Genetic Association (STREGA) studies initiative builds on the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement and provides additions to 12 of the 22 items on the STROBE checklist. The additions concern population stratification, genotyping errors, modeling haplotype variation, Hardy-Weinberg equilibrium, replication, selection of participants, rationale for choice of genes and variants, treatment effects in studying quantitative traits, statistical methods, relatedness, reporting of descriptive and outcome data, and the volume of data issues that are important to consider in genetic association studies. The STREGA recommendations (to not prescribe or dictate how a genetic association study Should be designed, but seek to enhance the transparency of its reporting, regardless of choices made during design, conduct, or analysis. (C) 2009 The Authors. Published by Elsevier Inc. All rights reserved.
AB - Making sense of rapidly evolving evidence on genetic associations is crucial to making genuine advances in human genomics and the eventual integration of this information in the practice of medicine and public health. Assessment of the strengths and weaknesses of this evidence, and hence, the ability to synthesize it, has been limited by inadequate reporting Of results. The STrengthening the REporting of Genetic Association (STREGA) studies initiative builds on the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement and provides additions to 12 of the 22 items on the STROBE checklist. The additions concern population stratification, genotyping errors, modeling haplotype variation, Hardy-Weinberg equilibrium, replication, selection of participants, rationale for choice of genes and variants, treatment effects in studying quantitative traits, statistical methods, relatedness, reporting of descriptive and outcome data, and the volume of data issues that are important to consider in genetic association studies. The STREGA recommendations (to not prescribe or dictate how a genetic association study Should be designed, but seek to enhance the transparency of its reporting, regardless of choices made during design, conduct, or analysis. (C) 2009 The Authors. Published by Elsevier Inc. All rights reserved.
M3 - Article
SN - 0895-4356
VL - 62
SP - 597
EP - 608
JO - Journal of Clinical Epidemiology
JF - Journal of Clinical Epidemiology
IS - 6
ER -
