TY - JOUR
T1 - Structure and Chromosomal Localization of the Human Anti-Müllerian Hormone Type II Receptor Gene
AU - Visser, Jenny A.
AU - Mcluskey, Anke
AU - van Beers, Tessa
AU - Olde Weghuis, Daniël
AU - Geurts van Kessel, Ad
AU - Grootegoed, Anton
AU - Themmen, Axel P.N.
N1 - Copyright © 1995 by Academic Press Inc. All rights of reproduction in any form reserved.
PY - 1995/10/24
Y1 - 1995/10/24
N2 - Using the rat anti-müllerian hormone type II receptor (AMHRII) cDNA as a probe, two overlapping lambda phage clones containing the AMHRII gene were isolated from a human genomic library. Sequence analysis of the exons was performed and the exon/intron boundaries were determined. The coding region was found to consist of 11 exons, divided over 8 kb. The genomic structure resembles that of the related activin type II receptor gene. The AMHRII gene was mapped to human chromosome 12q12-q13. The results reported are essential for identification of AMHRII gene alterations in patients with persistent müllerian duct syndrome.
AB - Using the rat anti-müllerian hormone type II receptor (AMHRII) cDNA as a probe, two overlapping lambda phage clones containing the AMHRII gene were isolated from a human genomic library. Sequence analysis of the exons was performed and the exon/intron boundaries were determined. The coding region was found to consist of 11 exons, divided over 8 kb. The genomic structure resembles that of the related activin type II receptor gene. The AMHRII gene was mapped to human chromosome 12q12-q13. The results reported are essential for identification of AMHRII gene alterations in patients with persistent müllerian duct syndrome.
UR - http://www.scopus.com/inward/record.url?scp=0028876950&partnerID=8YFLogxK
U2 - 10.1006/bbrc.1995.2567
DO - 10.1006/bbrc.1995.2567
M3 - Article
C2 - 7488027
AN - SCOPUS:0028876950
SN - 0006-291X
VL - 215
SP - 1029
EP - 1036
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 3
ER -