Structure and Chromosomal Localization of the Human Anti-Müllerian Hormone Type II Receptor Gene

Jenny A. Visser; Anke Mcluskey; Tessa van Beers; Daniël Olde Weghuis; Ad Geurts van Kessel; Anton Grootegoed; Axel P.N. Themmen

doi:10.1006/bbrc.1995.2567

Structure and Chromosomal Localization of the Human Anti-Müllerian Hormone Type II Receptor Gene

Jenny A. Visser^*
, Anke Mcluskey
, Tessa van Beers
, Daniël Olde Weghuis
, Ad Geurts van Kessel
, Anton Grootegoed
, Axel P.N. Themmen

^*Corresponding author for this work

Radboud University Medical Center
Erasmus University Medical Centre

Research output: Contribution to journal › Article › Academic › peer-review

30 Citations (Scopus)

Abstract

Using the rat anti-müllerian hormone type II receptor (AMHRII) cDNA as a probe, two overlapping lambda phage clones containing the AMHRII gene were isolated from a human genomic library. Sequence analysis of the exons was performed and the exon/intron boundaries were determined. The coding region was found to consist of 11 exons, divided over 8 kb. The genomic structure resembles that of the related activin type II receptor gene. The AMHRII gene was mapped to human chromosome 12q12-q13. The results reported are essential for identification of AMHRII gene alterations in patients with persistent müllerian duct syndrome.

Original language	English
Pages (from-to)	1029-1036
Number of pages	8
Journal	Biochemical and Biophysical Research Communications
Volume	215
Issue number	3
DOIs	https://doi.org/10.1006/bbrc.1995.2567
Publication status	Published - 24 Oct 1995

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title = "Structure and Chromosomal Localization of the Human Anti-M{\"u}llerian Hormone Type II Receptor Gene",

abstract = "Using the rat anti-m{\"u}llerian hormone type II receptor (AMHRII) cDNA as a probe, two overlapping lambda phage clones containing the AMHRII gene were isolated from a human genomic library. Sequence analysis of the exons was performed and the exon/intron boundaries were determined. The coding region was found to consist of 11 exons, divided over 8 kb. The genomic structure resembles that of the related activin type II receptor gene. The AMHRII gene was mapped to human chromosome 12q12-q13. The results reported are essential for identification of AMHRII gene alterations in patients with persistent m{\"u}llerian duct syndrome.",

author = "Visser, \{Jenny A.\} and Anke Mcluskey and \{van Beers\}, Tessa and \{Olde Weghuis\}, Dani{\"e}l and \{Geurts van Kessel\}, Ad and Anton Grootegoed and Themmen, \{Axel P.N.\}",

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AU - Visser, Jenny A.

AU - Mcluskey, Anke

AU - van Beers, Tessa

AU - Olde Weghuis, Daniël

AU - Geurts van Kessel, Ad

AU - Grootegoed, Anton

AU - Themmen, Axel P.N.

PY - 1995/10/24

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AB - Using the rat anti-müllerian hormone type II receptor (AMHRII) cDNA as a probe, two overlapping lambda phage clones containing the AMHRII gene were isolated from a human genomic library. Sequence analysis of the exons was performed and the exon/intron boundaries were determined. The coding region was found to consist of 11 exons, divided over 8 kb. The genomic structure resembles that of the related activin type II receptor gene. The AMHRII gene was mapped to human chromosome 12q12-q13. The results reported are essential for identification of AMHRII gene alterations in patients with persistent müllerian duct syndrome.

UR - https://www.scopus.com/pages/publications/0028876950

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JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

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ER -

Structure and Chromosomal Localization of the Human Anti-Müllerian Hormone Type II Receptor Gene

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