Small airways (<2 mm in diameter) are probably involved across almost all asthma severities and they show proportionally more structural and functional abnormalities with increasing asthma severity. The structural and functional alterations of the epithelium, extracellular matrix and airway smooth muscle in small airways of people with asthma have been described over many years using in vitro studies, animal models or imaging and modelling methods. The purpose of this review was to provide an overview of these observations and to outline several potential pathophysiological mechanisms regarding the role of small airways in asthma.
|Number of pages||18|
|Journal||European Respiratory Review|
|Publication status||Published - 31 Mar 2021|
Bibliographical noteFunding Information:
Support statement: Funding was received from Vectura Group plc. (unconditional grant for PhD research programme). Funding information for this article has been deposited with the Crossref Funder Registry.
© ERS 2021.