Structure and function of small airways in asthma patients revisited

Wytse van den Bosch, AL James, H.A.W.M. Tiddens

Research output: Contribution to journalArticleAcademicpeer-review

25 Citations (Scopus)
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Small airways (<2 mm in diameter) are probably involved across almost all asthma severities and they show proportionally more structural and functional abnormalities with increasing asthma severity. The structural and functional alterations of the epithelium, extracellular matrix and airway smooth muscle in small airways of people with asthma have been described over many years using in vitro studies, animal models or imaging and modelling methods. The purpose of this review was to provide an overview of these observations and to outline several potential pathophysiological mechanisms regarding the role of small airways in asthma.

Original languageEnglish
Article number200186
Pages (from-to)1-18
Number of pages18
JournalEuropean Respiratory Review
Issue number159
Publication statusPublished - 31 Mar 2021

Bibliographical note

Funding Information:
Support statement: Funding was received from Vectura Group plc. (unconditional grant for PhD research programme). Funding information for this article has been deposited with the Crossref Funder Registry.

Publisher Copyright:
© ERS 2021.

Research programs

  • EMC OR-01-54-02


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