Subamniotic Hemorrhage, a Possible New Presentation of Fetal and Neonatal Alloimmune Thrombocytopenia

Steven Giesbers; Manon Bos; Johan Bulten; Lotte van der Meeren; Joris van Drongelen

doi:10.1159/000521866

Subamniotic Hemorrhage, a Possible New Presentation of Fetal and Neonatal Alloimmune Thrombocytopenia

Steven Giesbers^*, Manon Bos, Johan Bulten, Lotte van der Meeren, Joris van Drongelen

^*Corresponding author for this work

Pathology

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

BACKGROUND: Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a rare fetal disease in which maternal antibodies directed toward fetal human platelet antigens (HPA) are formed during pregnancy and cause fetal thrombocytopenia. The diagnosis FNAIT is suspected when a fetus or neonate presents with signs of bleeding.

CASE: We describe a pregnancy complicated by a placental hematoma in the 20th week of gestation as the first manifestation of FNAIT. Further evaluation showed signs of germinal matrix hemorrhage and HPA-5b allo-antibodies. After the diagnosis, intravenous immunoglobulin was administered weekly and a healthy daughter was born at 37 weeks. Histopathological analysis revealed that the hematoma was caused by a subamniotic hemorrhage of fetal origin.

CONCLUSION: A subamniotic hematoma appears to be the first manifestation of FNAIT.

Original language	English
Pages (from-to)	60-64
Number of pages	5
Journal	Fetal Diagnosis and Therapy
Volume	49
Issue number	1-2
DOIs	https://doi.org/10.1159/000521866
Publication status	Published - 1 Apr 2022

Bibliographical note

Funding Information:
No financial support or funding was received for this article.

Publisher Copyright:
© 2022

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Cite this

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title = "Subamniotic Hemorrhage, a Possible New Presentation of Fetal and Neonatal Alloimmune Thrombocytopenia",

abstract = "BACKGROUND: Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a rare fetal disease in which maternal antibodies directed toward fetal human platelet antigens (HPA) are formed during pregnancy and cause fetal thrombocytopenia. The diagnosis FNAIT is suspected when a fetus or neonate presents with signs of bleeding.CASE: We describe a pregnancy complicated by a placental hematoma in the 20th week of gestation as the first manifestation of FNAIT. Further evaluation showed signs of germinal matrix hemorrhage and HPA-5b allo-antibodies. After the diagnosis, intravenous immunoglobulin was administered weekly and a healthy daughter was born at 37 weeks. Histopathological analysis revealed that the hematoma was caused by a subamniotic hemorrhage of fetal origin.CONCLUSION: A subamniotic hematoma appears to be the first manifestation of FNAIT.",

author = "Steven Giesbers and Manon Bos and Johan Bulten and \{van der Meeren\}, Lotte and \{van Drongelen\}, Joris",

note = "Funding Information: No financial support or funding was received for this article. Publisher Copyright: {\textcopyright} 2022",

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T1 - Subamniotic Hemorrhage, a Possible New Presentation of Fetal and Neonatal Alloimmune Thrombocytopenia

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AU - Bos, Manon

AU - Bulten, Johan

AU - van der Meeren, Lotte

AU - van Drongelen, Joris

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N2 - BACKGROUND: Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a rare fetal disease in which maternal antibodies directed toward fetal human platelet antigens (HPA) are formed during pregnancy and cause fetal thrombocytopenia. The diagnosis FNAIT is suspected when a fetus or neonate presents with signs of bleeding.CASE: We describe a pregnancy complicated by a placental hematoma in the 20th week of gestation as the first manifestation of FNAIT. Further evaluation showed signs of germinal matrix hemorrhage and HPA-5b allo-antibodies. After the diagnosis, intravenous immunoglobulin was administered weekly and a healthy daughter was born at 37 weeks. Histopathological analysis revealed that the hematoma was caused by a subamniotic hemorrhage of fetal origin.CONCLUSION: A subamniotic hematoma appears to be the first manifestation of FNAIT.

AB - BACKGROUND: Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a rare fetal disease in which maternal antibodies directed toward fetal human platelet antigens (HPA) are formed during pregnancy and cause fetal thrombocytopenia. The diagnosis FNAIT is suspected when a fetus or neonate presents with signs of bleeding.CASE: We describe a pregnancy complicated by a placental hematoma in the 20th week of gestation as the first manifestation of FNAIT. Further evaluation showed signs of germinal matrix hemorrhage and HPA-5b allo-antibodies. After the diagnosis, intravenous immunoglobulin was administered weekly and a healthy daughter was born at 37 weeks. Histopathological analysis revealed that the hematoma was caused by a subamniotic hemorrhage of fetal origin.CONCLUSION: A subamniotic hematoma appears to be the first manifestation of FNAIT.

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Subamniotic Hemorrhage, a Possible New Presentation of Fetal and Neonatal Alloimmune Thrombocytopenia

Abstract

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