Subclass IgG to motor gangliosides related to infection and clinical course in Guillain-Barre syndrome

B.C. Jacobs; M Koga; Wouter Rijs; K Geleijns; PA van Doom; HJ Willison; N Yuki

doi:10.1016/j.jneuroim.2007.11.017

Subclass IgG to motor gangliosides related to infection and clinical course in Guillain-Barre syndrome

B.C. Jacobs, M Koga, Wouter Rijs, K Geleijns, PA van Doom, HJ Willison, N Yuki

Neurology

Research output: Contribution to journal › Article › Academic › peer-review

52 Citations (Scopus)

Abstract

In 176 patients with Guillain-Barre syndrome the subclass and cross-reactivity of serum IgG antibodies to motor gangliosides was related to preceding infections and clinical phenotypes. Two subgroups of patients were identified. Presence of only IgG I antibodies was related to diarrhea, positive Campylobacter serology, cross-reactive antibodies to C jejuni lipo-oligosaccharides and poor outcome. In contrast, having both IgG1 and IgG3 antibodies was related to upper respiratory tract infections, cross-reactive antibodies to Haemophilus influenzae lipo-oligosaccharides and better outcome. These findings support a model in which C. jejuni and H. influenzae infections induce two distinct patterns of cross-reactive antibodies with different clinical outcome. (C) 2007 Elsevier B.V. All rights reserved.

Original language	Undefined/Unknown
Pages (from-to)	181-190
Number of pages	10
Journal	Journal of Neuroimmunology
Volume	194
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2007.11.017
Publication status	Published - 2008

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EMC MM-02-72-02
EMC MM-04-44-02

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This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.jneuroim.2007.11.017

http://hdl.handle.net/1765/29405

Cite this

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title = "Subclass IgG to motor gangliosides related to infection and clinical course in Guillain-Barre syndrome",

abstract = "In 176 patients with Guillain-Barre syndrome the subclass and cross-reactivity of serum IgG antibodies to motor gangliosides was related to preceding infections and clinical phenotypes. Two subgroups of patients were identified. Presence of only IgG I antibodies was related to diarrhea, positive Campylobacter serology, cross-reactive antibodies to C jejuni lipo-oligosaccharides and poor outcome. In contrast, having both IgG1 and IgG3 antibodies was related to upper respiratory tract infections, cross-reactive antibodies to Haemophilus influenzae lipo-oligosaccharides and better outcome. These findings support a model in which C. jejuni and H. influenzae infections induce two distinct patterns of cross-reactive antibodies with different clinical outcome. (C) 2007 Elsevier B.V. All rights reserved.",

author = "B.C. Jacobs and M Koga and Wouter Rijs and K Geleijns and {van Doom}, PA and HJ Willison and N Yuki",

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T1 - Subclass IgG to motor gangliosides related to infection and clinical course in Guillain-Barre syndrome

AU - Jacobs, B.C.

AU - Koga, M

AU - Rijs, Wouter

AU - Geleijns, K

AU - van Doom, PA

AU - Willison, HJ

AU - Yuki, N

PY - 2008

Y1 - 2008

N2 - In 176 patients with Guillain-Barre syndrome the subclass and cross-reactivity of serum IgG antibodies to motor gangliosides was related to preceding infections and clinical phenotypes. Two subgroups of patients were identified. Presence of only IgG I antibodies was related to diarrhea, positive Campylobacter serology, cross-reactive antibodies to C jejuni lipo-oligosaccharides and poor outcome. In contrast, having both IgG1 and IgG3 antibodies was related to upper respiratory tract infections, cross-reactive antibodies to Haemophilus influenzae lipo-oligosaccharides and better outcome. These findings support a model in which C. jejuni and H. influenzae infections induce two distinct patterns of cross-reactive antibodies with different clinical outcome. (C) 2007 Elsevier B.V. All rights reserved.

AB - In 176 patients with Guillain-Barre syndrome the subclass and cross-reactivity of serum IgG antibodies to motor gangliosides was related to preceding infections and clinical phenotypes. Two subgroups of patients were identified. Presence of only IgG I antibodies was related to diarrhea, positive Campylobacter serology, cross-reactive antibodies to C jejuni lipo-oligosaccharides and poor outcome. In contrast, having both IgG1 and IgG3 antibodies was related to upper respiratory tract infections, cross-reactive antibodies to Haemophilus influenzae lipo-oligosaccharides and better outcome. These findings support a model in which C. jejuni and H. influenzae infections induce two distinct patterns of cross-reactive antibodies with different clinical outcome. (C) 2007 Elsevier B.V. All rights reserved.

U2 - 10.1016/j.jneuroim.2007.11.017

DO - 10.1016/j.jneuroim.2007.11.017

M3 - Article

C2 - 18178257

SN - 0165-5728

VL - 194

SP - 181

EP - 190

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

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