Subregion-specific dendritic spine abnormalities in the hippocampus of Fmr1 KO mice

Geertruida Levenga; Femke de Vrij; Ronald Buijsen; T (Tracy) Li; Ingeborg Bakker; Andreea Pop; Ben Oostra; Rob Willemsen

doi:10.1016/j.nlm.2011.02.009

Subregion-specific dendritic spine abnormalities in the hippocampus of Fmr1 KO mice

Geertruida Levenga, Femke de Vrij, Ronald Buijsen, T (Tracy) Li, Ingeborg Bakker, Andreea Pop, Ben Oostra, Rob Willemsen

Research output: Contribution to journal › Article › Academic › peer-review

46 Citations (Scopus)

Abstract

Fragile X syndrome (FXS) is the most common inherited form of mental retardation and is caused by the lack of fragile X mental retardation protein (FMRP). In the brain, spine abnormalities have been reported in both patients with FXS and Fmr1 knockout mice. This altered spine morphology has been linked to disturbed synaptic transmission related to altered signaling in the excitatory metabotropic glutamate receptor 5 (mGluR5) pathway. We investigated hippocampal protrusion morphology in adult Fmr1 knockout mice. Our results show a hippocampal CA1-specific altered protrusion phenotype, which was absent in the CA3 region of the hippocampus. This suggests a subregion-specific function of FMRP in synaptic plasticity in the brain. (C) 2011 Elsevier Inc. All rights reserved.

Original language	Undefined/Unknown
Pages (from-to)	467-472
Number of pages	6
Journal	Neurobiology of Learning and Memory
Volume	95
Issue number	4
DOIs	https://doi.org/10.1016/j.nlm.2011.02.009
Publication status	Published - 2011

Access to Document

10.1016/j.nlm.2011.02.009

http://hdl.handle.net/1765/34211

Cite this

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title = "Subregion-specific dendritic spine abnormalities in the hippocampus of Fmr1 KO mice",

abstract = "Fragile X syndrome (FXS) is the most common inherited form of mental retardation and is caused by the lack of fragile X mental retardation protein (FMRP). In the brain, spine abnormalities have been reported in both patients with FXS and Fmr1 knockout mice. This altered spine morphology has been linked to disturbed synaptic transmission related to altered signaling in the excitatory metabotropic glutamate receptor 5 (mGluR5) pathway. We investigated hippocampal protrusion morphology in adult Fmr1 knockout mice. Our results show a hippocampal CA1-specific altered protrusion phenotype, which was absent in the CA3 region of the hippocampus. This suggests a subregion-specific function of FMRP in synaptic plasticity in the brain. (C) 2011 Elsevier Inc. All rights reserved.",

author = "Geertruida Levenga and {de Vrij}, Femke and Ronald Buijsen and Li, {T (Tracy)} and Ingeborg Bakker and Andreea Pop and Ben Oostra and Rob Willemsen",

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T1 - Subregion-specific dendritic spine abnormalities in the hippocampus of Fmr1 KO mice

AU - Levenga, Geertruida

AU - de Vrij, Femke

AU - Buijsen, Ronald

AU - Li, T (Tracy)

AU - Bakker, Ingeborg

AU - Pop, Andreea

AU - Oostra, Ben

AU - Willemsen, Rob

PY - 2011

Y1 - 2011

N2 - Fragile X syndrome (FXS) is the most common inherited form of mental retardation and is caused by the lack of fragile X mental retardation protein (FMRP). In the brain, spine abnormalities have been reported in both patients with FXS and Fmr1 knockout mice. This altered spine morphology has been linked to disturbed synaptic transmission related to altered signaling in the excitatory metabotropic glutamate receptor 5 (mGluR5) pathway. We investigated hippocampal protrusion morphology in adult Fmr1 knockout mice. Our results show a hippocampal CA1-specific altered protrusion phenotype, which was absent in the CA3 region of the hippocampus. This suggests a subregion-specific function of FMRP in synaptic plasticity in the brain. (C) 2011 Elsevier Inc. All rights reserved.

AB - Fragile X syndrome (FXS) is the most common inherited form of mental retardation and is caused by the lack of fragile X mental retardation protein (FMRP). In the brain, spine abnormalities have been reported in both patients with FXS and Fmr1 knockout mice. This altered spine morphology has been linked to disturbed synaptic transmission related to altered signaling in the excitatory metabotropic glutamate receptor 5 (mGluR5) pathway. We investigated hippocampal protrusion morphology in adult Fmr1 knockout mice. Our results show a hippocampal CA1-specific altered protrusion phenotype, which was absent in the CA3 region of the hippocampus. This suggests a subregion-specific function of FMRP in synaptic plasticity in the brain. (C) 2011 Elsevier Inc. All rights reserved.

U2 - 10.1016/j.nlm.2011.02.009

DO - 10.1016/j.nlm.2011.02.009

M3 - Article

SN - 1074-7427

VL - 95

SP - 467

EP - 472

JO - Neurobiology of Learning and Memory

JF - Neurobiology of Learning and Memory

IS - 4

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