Subregion-specific dendritic spine abnormalities in the hippocampus of Fmr1 KO mice

Geertruida Levenga, Femke de Vrij, Ronald Buijsen, T (Tracy) Li, Ingeborg Bakker, Andreea Pop, Ben Oostra, Rob Willemsen

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45 Citations (Scopus)

Abstract

Fragile X syndrome (FXS) is the most common inherited form of mental retardation and is caused by the lack of fragile X mental retardation protein (FMRP). In the brain, spine abnormalities have been reported in both patients with FXS and Fmr1 knockout mice. This altered spine morphology has been linked to disturbed synaptic transmission related to altered signaling in the excitatory metabotropic glutamate receptor 5 (mGluR5) pathway. We investigated hippocampal protrusion morphology in adult Fmr1 knockout mice. Our results show a hippocampal CA1-specific altered protrusion phenotype, which was absent in the CA3 region of the hippocampus. This suggests a subregion-specific function of FMRP in synaptic plasticity in the brain. (C) 2011 Elsevier Inc. All rights reserved.
Original languageUndefined/Unknown
Pages (from-to)467-472
Number of pages6
JournalNeurobiology of Learning and Memory
Volume95
Issue number4
DOIs
Publication statusPublished - 2011

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