Sunny Holidays before and after Melanoma Diagnosis Are Respectively Associated with Lower Breslow Thickness and Lower Relapse Rates in Italy

S Gandini; Esther Vries; G Tosti; E Botteri; G Spadola; P Maisonneuve; C Martinoli; Arjen Joosse; PF Ferrucci; F Baldini; E Cocorocchio; E Pennacchioli; F Cataldo; B Bazolli; A (Alessandra) Clerici; M Barberis; V Bataille; A Testori

doi:10.1371/journal.pone.0078820

Sunny Holidays before and after Melanoma Diagnosis Are Respectively Associated with Lower Breslow Thickness and Lower Relapse Rates in Italy

S Gandini, Esther Vries, G Tosti, E Botteri, G Spadola, P Maisonneuve, C Martinoli, Arjen Joosse, PF Ferrucci, F Baldini, E Cocorocchio, E Pennacchioli, F Cataldo, B Bazolli, A (Alessandra) Clerici, M Barberis, V Bataille, A Testori

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Abstract

Background: Previous studies have reported an association between sun exposure and improved cutaneous melanoma (CM) survival. We analysed the association of UV exposure with prognostic factors and outcome in a large melanoma cohort. Methods: A questionnaire was given to 289 (42%) CM patients at diagnosis (Group 1) and to 402 CM patients (58%) during follow-up (Group 2). Analyses were carried out to investigate the associations between sun exposure and melanoma prognostic factors and survival. Results: Holidays in the sun two years before CM diagnosis were significantly associated with lower Breslow thickness (p=0.003), after multiple adjustment. Number of weeks of sunny holidays was also significantly and inversely associated with thickness in a dose-dependent manner (p=0.007). However when stratifying by gender this association was found only among women (p=0.0004) the risk of CM recurrence in both sexes was significantly lower in patients (n=271) who had holidays in the sun after d

Original language	Undefined/Unknown
Journal	PLoS One (print)
Volume	8
Issue number	11
DOIs	https://doi.org/10.1371/journal.pone.0078820
Publication status	Published - 2013

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EMC NIHES-02-65-02

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Cite this

Gandini, S., Vries, E., Tosti, G., Botteri, E., Spadola, G., Maisonneuve, P., Martinoli, C., Joosse, A., Ferrucci, PF., Baldini, F., Cocorocchio, E., Pennacchioli, E., Cataldo, F., Bazolli, B., Clerici, A., Barberis, M., Bataille, V., & Testori, A. (2013). Sunny Holidays before and after Melanoma Diagnosis Are Respectively Associated with Lower Breslow Thickness and Lower Relapse Rates in Italy. PLoS One (print), 8(11). https://doi.org/10.1371/journal.pone.0078820

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title = "Sunny Holidays before and after Melanoma Diagnosis Are Respectively Associated with Lower Breslow Thickness and Lower Relapse Rates in Italy",

abstract = "Background: Previous studies have reported an association between sun exposure and improved cutaneous melanoma (CM) survival. We analysed the association of UV exposure with prognostic factors and outcome in a large melanoma cohort. Methods: A questionnaire was given to 289 (42%) CM patients at diagnosis (Group 1) and to 402 CM patients (58%) during follow-up (Group 2). Analyses were carried out to investigate the associations between sun exposure and melanoma prognostic factors and survival. Results: Holidays in the sun two years before CM diagnosis were significantly associated with lower Breslow thickness (p=0.003), after multiple adjustment. Number of weeks of sunny holidays was also significantly and inversely associated with thickness in a dose-dependent manner (p=0.007). However when stratifying by gender this association was found only among women (p=0.0004) the risk of CM recurrence in both sexes was significantly lower in patients (n=271) who had holidays in the sun after d",

author = "S Gandini and Esther Vries and G Tosti and E Botteri and G Spadola and P Maisonneuve and C Martinoli and Arjen Joosse and PF Ferrucci and F Baldini and E Cocorocchio and E Pennacchioli and F Cataldo and B Bazolli and Clerici, {A (Alessandra)} and M Barberis and V Bataille and A Testori",

year = "2013",

doi = "10.1371/journal.pone.0078820",

language = "Undefined/Unknown",

volume = "8",

journal = "PLoS One (print)",

issn = "1932-6203",

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Gandini, S, Vries, E, Tosti, G, Botteri, E, Spadola, G, Maisonneuve, P, Martinoli, C, Joosse, A, Ferrucci, PF, Baldini, F, Cocorocchio, E, Pennacchioli, E, Cataldo, F, Bazolli, B, Clerici, A, Barberis, M, Bataille, V & Testori, A 2013, 'Sunny Holidays before and after Melanoma Diagnosis Are Respectively Associated with Lower Breslow Thickness and Lower Relapse Rates in Italy', PLoS One (print), vol. 8, no. 11. https://doi.org/10.1371/journal.pone.0078820

TY - JOUR

T1 - Sunny Holidays before and after Melanoma Diagnosis Are Respectively Associated with Lower Breslow Thickness and Lower Relapse Rates in Italy

AU - Gandini, S

AU - Vries, Esther

AU - Tosti, G

AU - Botteri, E

AU - Spadola, G

AU - Maisonneuve, P

AU - Martinoli, C

AU - Joosse, Arjen

AU - Ferrucci, PF

AU - Baldini, F

AU - Cocorocchio, E

AU - Pennacchioli, E

AU - Cataldo, F

AU - Bazolli, B

AU - Clerici, A (Alessandra)

AU - Barberis, M

AU - Bataille, V

AU - Testori, A

PY - 2013

Y1 - 2013

N2 - Background: Previous studies have reported an association between sun exposure and improved cutaneous melanoma (CM) survival. We analysed the association of UV exposure with prognostic factors and outcome in a large melanoma cohort. Methods: A questionnaire was given to 289 (42%) CM patients at diagnosis (Group 1) and to 402 CM patients (58%) during follow-up (Group 2). Analyses were carried out to investigate the associations between sun exposure and melanoma prognostic factors and survival. Results: Holidays in the sun two years before CM diagnosis were significantly associated with lower Breslow thickness (p=0.003), after multiple adjustment. Number of weeks of sunny holidays was also significantly and inversely associated with thickness in a dose-dependent manner (p=0.007). However when stratifying by gender this association was found only among women (p=0.0004) the risk of CM recurrence in both sexes was significantly lower in patients (n=271) who had holidays in the sun after d

AB - Background: Previous studies have reported an association between sun exposure and improved cutaneous melanoma (CM) survival. We analysed the association of UV exposure with prognostic factors and outcome in a large melanoma cohort. Methods: A questionnaire was given to 289 (42%) CM patients at diagnosis (Group 1) and to 402 CM patients (58%) during follow-up (Group 2). Analyses were carried out to investigate the associations between sun exposure and melanoma prognostic factors and survival. Results: Holidays in the sun two years before CM diagnosis were significantly associated with lower Breslow thickness (p=0.003), after multiple adjustment. Number of weeks of sunny holidays was also significantly and inversely associated with thickness in a dose-dependent manner (p=0.007). However when stratifying by gender this association was found only among women (p=0.0004) the risk of CM recurrence in both sexes was significantly lower in patients (n=271) who had holidays in the sun after d

U2 - 10.1371/journal.pone.0078820

DO - 10.1371/journal.pone.0078820

M3 - Article

C2 - 24223851

SN - 1932-6203

VL - 8

JO - PLoS One (print)

JF - PLoS One (print)

IS - 11

ER -