Susceptibility to Guillain-Barre syndrome is not associated with CD1A and CD1E gene polymorphisms

ML Kuijf; CPW Geleijns; N (Noureddine) Ennaji; Wouter Rijs; Pieter van Doorn; B.C. Jacobs

doi:10.1016/j.jneuroim.2008.08.013

Susceptibility to Guillain-Barre syndrome is not associated with CD1A and CD1E gene polymorphisms

ML Kuijf, CPW Geleijns, N (Noureddine) Ennaji, Wouter Rijs, Pieter van Doorn, B.C. Jacobs

Research output: Contribution to journal › Article › Academic › peer-review

29 Citations (Scopus)

Abstract

Immune responses to microbial glycolipids that cross-react to neural epitopes may trigger the Guillain-Barr syndrome (GBS). CD1 molecules are involved in antigen presentation of glycolipids and variation in CD1 genes was recently reported to confer susceptibility to develop GBS. This hypothesis was tested by comparing single nucleotide polymorphisms (SNPs) of CD1A and CD1E in 312 well defined GBS patients and 212 healthy controls. SNPs in CD1A and CD1E were not associated with GBS Susceptibility, specific clinical Subgroups, anti-ganglioside antibodies. antecedent infections and prognosis. Based on this study, CD1 polymorphisms are not a susceptibility or disease modifying factor in GBS. (C) 2008 Elsevier B.V. All rights reserved.

Original language	Undefined/Unknown
Pages (from-to)	110-112
Number of pages	3
Journal	Journal of Neuroimmunology
Volume	205
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2008.08.013
Publication status	Published - 2008

Research programs

EMC MM-02-72-02
EMC MM-04-44-02

Access to Document

10.1016/j.jneuroim.2008.08.013

http://hdl.handle.net/1765/29274

Cite this

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title = "Susceptibility to Guillain-Barre syndrome is not associated with CD1A and CD1E gene polymorphisms",

abstract = "Immune responses to microbial glycolipids that cross-react to neural epitopes may trigger the Guillain-Barr syndrome (GBS). CD1 molecules are involved in antigen presentation of glycolipids and variation in CD1 genes was recently reported to confer susceptibility to develop GBS. This hypothesis was tested by comparing single nucleotide polymorphisms (SNPs) of CD1A and CD1E in 312 well defined GBS patients and 212 healthy controls. SNPs in CD1A and CD1E were not associated with GBS Susceptibility, specific clinical Subgroups, anti-ganglioside antibodies. antecedent infections and prognosis. Based on this study, CD1 polymorphisms are not a susceptibility or disease modifying factor in GBS. (C) 2008 Elsevier B.V. All rights reserved.",

author = "ML Kuijf and CPW Geleijns and Ennaji, {N (Noureddine)} and Wouter Rijs and {van Doorn}, Pieter and B.C. Jacobs",

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T1 - Susceptibility to Guillain-Barre syndrome is not associated with CD1A and CD1E gene polymorphisms

AU - Kuijf, ML

AU - Geleijns, CPW

AU - Ennaji, N (Noureddine)

AU - Rijs, Wouter

AU - van Doorn, Pieter

AU - Jacobs, B.C.

PY - 2008

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AB - Immune responses to microbial glycolipids that cross-react to neural epitopes may trigger the Guillain-Barr syndrome (GBS). CD1 molecules are involved in antigen presentation of glycolipids and variation in CD1 genes was recently reported to confer susceptibility to develop GBS. This hypothesis was tested by comparing single nucleotide polymorphisms (SNPs) of CD1A and CD1E in 312 well defined GBS patients and 212 healthy controls. SNPs in CD1A and CD1E were not associated with GBS Susceptibility, specific clinical Subgroups, anti-ganglioside antibodies. antecedent infections and prognosis. Based on this study, CD1 polymorphisms are not a susceptibility or disease modifying factor in GBS. (C) 2008 Elsevier B.V. All rights reserved.

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DO - 10.1016/j.jneuroim.2008.08.013

M3 - Article

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SN - 0165-5728

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JO - Journal of Neuroimmunology

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