SYMPHONY consortium: Orchestrating personalized treatment for patients with bleeding disorders

Marjon H. Cnossen*, Iris van Moort, Simone H. Reitsma, Moniek P.M. de Maat, Roger E.G. Schutgens, Rolf T. Urbanus, Hester F. Lingsma, Ron A.A. Mathot, Samantha C. Gouw, Karina Meijer, Annelien L. Bredenoord, Rieke van der Graaf, Karin Fijnvandraat, Alexander B. Meijer, Emile van den Akker, Ruben Bierings, Jeroen C.J. Eikenboom, Maartje van den Biggelaar, Masja de Haas, Jan VoorbergFrank W.G. Leebeek

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Background: Treatment choices for individual patients with an inborn bleeding disorder are increasingly challenging due to increasing options and rising costs for society. We have initiated an integrated interdisciplinary national research program. Objectives: The SYMPHONY consortium strives to orchestrate personalized treatment in patients with an inborn bleeding disorder, by unraveling the mechanisms behind interindividual variations of bleeding phenotype. Patients: The SYMPHONY consortium will investigate patients with an inborn bleeding disorder, both diagnosed and not yet diagnosed. Results: Research questions are categorized under the themes: (1) diagnosis, (2) treatment, and (3) fundamental research, and consist of work packages addressing specific domains. Importantly, collaborations between patients and talented researchers from different areas of expertise promise to augment the impact of the SYMPHONY consortium, leading to unique interactions and intellectual property. Conclusions: SYMPHONY will perform research on all aspects of care, treatment individualization in patients with inborn bleeding disorders, as well as diagnostic innovations and results of molecular genetics and cellular model technology with regard to the hemostatic process. We believe that these research investments will lead to health-care innovations with long-term clinical and societal impact.

This consortium has been made possible by a governmental, competitive grant from the Netherlands Organization for Scientific Research (NWO) within the framework of the NWA-ORC Call grant agreement NWA.1160.18.038.

Original languageEnglish
Pages (from-to)2001-2011
Number of pages11
JournalJournal of Thrombosis and Haemostasis
Issue number9
Early online date2 Jun 2022
Publication statusPublished - 1 Sept 2022

Bibliographical note

... for the SYMPHONY consortium

Funding Information:
This research received funding from the NWO in the framework of the NWA‐ORC Call grant agreement NWA.1160.18.038. Principal investigator: Dr. M.H. Cnossen. Project manager: Dr. S.H. Reitsma.

Publisher Copyright:
© 2022 The Authors. Journal of Thrombosis and Haemostasis published by Wiley Periodicals LLC on behalf of International Society on Thrombosis and Haemostasis.


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