Synthetic glycans provide insight into the binding properties of toxic serum antibodies

Geert Jan Boons; Bart C. Jacobs

doi:10.1038/s44160-023-00395-3

Synthetic glycans provide insight into the binding properties of toxic serum antibodies

Geert Jan Boons
, Bart C. Jacobs

Utrecht University

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

A chemoenzymatic strategy is introduced whereby a glycan backbone is assembled enzymatically to give a core oligosaccharide that is subjected to chemical manipulations to install terminal epitopes. A library of oligosaccharides
containing the human natural killer-1 epitope was synthesized, enabling evaluation of the binding specificities of serum antibodies of patients with anti-myelin-
associated glycoprotein neuropathy.

Original language	English
Pages (from-to)	15-16
Number of pages	2
Journal	Nature Synthesis
Volume	3
Issue number	1
Early online date	2 Oct 2023
DOIs	https://doi.org/10.1038/s44160-023-00395-3
Publication status	Published - Jan 2024

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369-NatSynth Briefing 2023 onlineFinal published version, 0.99 MBLicence: Article 25fa Dutch Copyright Act

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abstract = "A chemoenzymatic strategy is introduced whereby a glycan backbone is assembled enzymatically to give a core oligosaccharide that is subjected to chemical manipulations to install terminal epitopes. A library of oligosaccharides containing the human natural killer-1 epitope was synthesized, enabling evaluation of the binding specificities of serum antibodies of patients with anti-myelin- associated glycoprotein neuropathy.",

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Synthetic glycans provide insight into the binding properties of toxic serum antibodies

Abstract

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