Systemic administration of oxytocin reduces basal and lipopolysaccharide-induced ghrelin levels in healthy men

G Vila, M Riedl, M Resl, Aart Jan Lelij, Leo Hofland, M Clodi, A Luger

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Oxytocin (OXT) and ghrelin have several common properties such as the involvement in the first phase response to stressors, in appetite regulation, and in the modulation of neural functions. Despite a recent study showing that intraventricular administration of ghrelin activates OXT neurons, little is known on the cross-talk between these two peptides. Here, we investigated the role of the i.v. administration of OXT on circulating ghrelin concentrations under fasting conditions and during the lipopolysaccharide (LPS)-induced endotoxenia. A randomized placebo-controlled cross-over study was performed in ten healthy men. In four study sessions, the participants received once placebo, once OXT (1 pmol/kg per thin over 90 min), once LPS (2 ng/kg), and once both OXT and LPS. Plasma ghrelin, glucose, and free fatty acid (FFA) levels were treasured at regular intervals during the first 6 h following the LPS bolus. Systemic administration of OXT decreased within 1 h plasma ghrelin levels (611 +/- 54 vs 697 +/- 52 pg/ml in placebo days, P=0.013) and increased plasma glucose and FFA concentrations (P=0.002 and P=0.005 respectively). OXT also reduced the LPS-induced surge in ghrelin at tine point 2 h (P=0.021). In summary, i.v. administration of OXT decreases circulating levels of ghrelin during fasting, as well as following LPS-induced endotoxemia in healthy men. The cross-talk between OXT and ghrelin aright be important in the regulation of energy homeostasis and stress responses. Journal of Endocrinology (2009) 203, 175-179
Original languageUndefined/Unknown
Pages (from-to)175-179
Number of pages5
JournalJournal of Endocrinology
Issue number1
Publication statusPublished - 2009

Research programs

  • EMC MM-01-39-01
  • EMC MM-01-39-04

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