TY - JOUR
T1 - Systemic ghrelin levels in subjects with growth hormone deficiency are not modified by one year of growth hormone replacement therapy
AU - Janssen, Joop A.M.J.L.
AU - van der Toorn, Fanny M.
AU - Hofland, Leo J.
AU - van Koetsveld, Peter
AU - Broglio, Fabio
AU - Ghigo, Ezio
AU - Lamberts, Steven W.J.
AU - van der Lely, Aart-Jan
N1 - © 2001 Society of the European Journal of Endocrinology
PY - 2001/12
Y1 - 2001/12
N2 - We did not observe elevated ghrelin levels in adult GHD subjects and GH replacement therapy did not modify circulating ghrelin levels, despite significant decreases in body fat mass and percentage body fat. It is conceivable that the lack of ghrelin modifications after long-term GH therapy was due to the reduction of adiposity and insulin on one hand, and increased GH secretion on the other. However, it is still possible that systemic ghrelin is involved in the development of obesity, both in normal and GHD subjects.
AB - We did not observe elevated ghrelin levels in adult GHD subjects and GH replacement therapy did not modify circulating ghrelin levels, despite significant decreases in body fat mass and percentage body fat. It is conceivable that the lack of ghrelin modifications after long-term GH therapy was due to the reduction of adiposity and insulin on one hand, and increased GH secretion on the other. However, it is still possible that systemic ghrelin is involved in the development of obesity, both in normal and GHD subjects.
UR - https://www.semanticscholar.org/paper/Systemic-ghrelin-levels-in-subjects-with-growth-are-Janssen-Toorn/80fb984d2393aa8cdbc3db320ab921d6b69f65bf
U2 - 10.1530/eje.0.1450711
DO - 10.1530/eje.0.1450711
M3 - Article
C2 - 11720895
SN - 0804-4643
VL - 145
SP - 711
EP - 716
JO - European Journal of Endocrinology
JF - European Journal of Endocrinology
ER -
