T-Cell Infiltration Correlates with CXCL10 Expression in Ganglia of Cynomolgus Macaques with Reactivated Simian Varicella Virus

Werner Ouwendijk; A Abendroth; V Traina-Dorge; Sarah Getu; M Steain; M Wellish; Arno Andeweg; Ab Osterhaus; D Gilden; Georges Verjans; R Mahalingam

doi:10.1128/JVI.03181-12

T-Cell Infiltration Correlates with CXCL10 Expression in Ganglia of Cynomolgus Macaques with Reactivated Simian Varicella Virus

Werner Ouwendijk, A Abendroth, V Traina-Dorge, Sarah Getu, M Steain, M Wellish, Arno Andeweg, Ab Osterhaus, D Gilden, Georges Verjans, R Mahalingam

Virology

Research output: Contribution to journal › Article › Academic › peer-review

30 Citations (Scopus)

Abstract

Ganglia of monkeys with reactivated simian varicella virus (SVV) contained more CD8 than CD4 T cells around neurons. The abundance of CD8 T cells was greater less than 2 months after reactivation than that at later times and correlated with that of CXCL10 RNA but not with those of SVV protein or open reading frame 61 (ORF61) antisense RNA. CXCL10 RNA colocalized with T-cell clusters. After SVV reactivation, transient T-cell infiltration, possibly mediated by CXCL10, parallels varicella zoster virus (VZV) reactivation in humans.

Original language	Undefined/Unknown
Pages (from-to)	2979-2982
Number of pages	4
Journal	Journal of Virology
Volume	87
Issue number	5
DOIs	https://doi.org/10.1128/JVI.03181-12
Publication status	Published - 2013

Research programs

EMC MM-04-27-01

Access to Document

10.1128/JVI.03181-12

http://hdl.handle.net/1765/64955

Cite this

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title = "T-Cell Infiltration Correlates with CXCL10 Expression in Ganglia of Cynomolgus Macaques with Reactivated Simian Varicella Virus",

abstract = "Ganglia of monkeys with reactivated simian varicella virus (SVV) contained more CD8 than CD4 T cells around neurons. The abundance of CD8 T cells was greater less than 2 months after reactivation than that at later times and correlated with that of CXCL10 RNA but not with those of SVV protein or open reading frame 61 (ORF61) antisense RNA. CXCL10 RNA colocalized with T-cell clusters. After SVV reactivation, transient T-cell infiltration, possibly mediated by CXCL10, parallels varicella zoster virus (VZV) reactivation in humans.",

author = "Werner Ouwendijk and A Abendroth and V Traina-Dorge and Sarah Getu and M Steain and M Wellish and Arno Andeweg and Ab Osterhaus and D Gilden and Georges Verjans and R Mahalingam",

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doi = "10.1128/JVI.03181-12",

language = "Undefined/Unknown",

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T1 - T-Cell Infiltration Correlates with CXCL10 Expression in Ganglia of Cynomolgus Macaques with Reactivated Simian Varicella Virus

AU - Ouwendijk, Werner

AU - Abendroth, A

AU - Traina-Dorge, V

AU - Getu, Sarah

AU - Steain, M

AU - Wellish, M

AU - Andeweg, Arno

AU - Osterhaus, Ab

AU - Gilden, D

AU - Verjans, Georges

AU - Mahalingam, R

PY - 2013

Y1 - 2013

N2 - Ganglia of monkeys with reactivated simian varicella virus (SVV) contained more CD8 than CD4 T cells around neurons. The abundance of CD8 T cells was greater less than 2 months after reactivation than that at later times and correlated with that of CXCL10 RNA but not with those of SVV protein or open reading frame 61 (ORF61) antisense RNA. CXCL10 RNA colocalized with T-cell clusters. After SVV reactivation, transient T-cell infiltration, possibly mediated by CXCL10, parallels varicella zoster virus (VZV) reactivation in humans.

AB - Ganglia of monkeys with reactivated simian varicella virus (SVV) contained more CD8 than CD4 T cells around neurons. The abundance of CD8 T cells was greater less than 2 months after reactivation than that at later times and correlated with that of CXCL10 RNA but not with those of SVV protein or open reading frame 61 (ORF61) antisense RNA. CXCL10 RNA colocalized with T-cell clusters. After SVV reactivation, transient T-cell infiltration, possibly mediated by CXCL10, parallels varicella zoster virus (VZV) reactivation in humans.

U2 - 10.1128/JVI.03181-12

DO - 10.1128/JVI.03181-12

M3 - Article

C2 - 23269790

SN - 0022-538X

VL - 87

SP - 2979

EP - 2982

JO - Journal of Virology

JF - Journal of Virology

IS - 5

ER -