T-Cell Infiltration Correlates with CXCL10 Expression in Ganglia of Cynomolgus Macaques with Reactivated Simian Varicella Virus

Werner Ouwendijk, A Abendroth, V Traina-Dorge, Sarah Getu, M Steain, M Wellish, Arno Andeweg, Ab Osterhaus, D Gilden, Georges Verjans, R Mahalingam

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Ganglia of monkeys with reactivated simian varicella virus (SVV) contained more CD8 than CD4 T cells around neurons. The abundance of CD8 T cells was greater less than 2 months after reactivation than that at later times and correlated with that of CXCL10 RNA but not with those of SVV protein or open reading frame 61 (ORF61) antisense RNA. CXCL10 RNA colocalized with T-cell clusters. After SVV reactivation, transient T-cell infiltration, possibly mediated by CXCL10, parallels varicella zoster virus (VZV) reactivation in humans.
Original languageUndefined/Unknown
Pages (from-to)2979-2982
Number of pages4
JournalJournal of Virology
Issue number5
Publication statusPublished - 2013

Research programs

  • EMC MM-04-27-01

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