TY - JOUR
T1 - T-cell surveillance of the human brain in health and multiple sclerosis
AU - Smolders, Joost
AU - van Luijn, Marvin M.
AU - Hsiao, Cheng Chih
AU - Hamann, Jörg
N1 - Publisher Copyright:© 2022, The Author(s).
PY - 2022/11
Y1 - 2022/11
N2 - Circulating and tissue-resident T cells collaborate in the protection of tissues against harmful infections and malignant transformation but also can instigate autoimmune reactions. Similar roles for T cells in the brain have been less evident due to the compartmentized organization of the central nervous system (CNS). In recent years, beneficial as well as occasional, detrimental effects of T-cell-targeting drugs in people with early multiple sclerosis (MS) have increased interest in T cells patrolling the CNS. Next to studies focusing on T cells in the cerebrospinal fluid, phenotypic characteristics of T cells located in the perivascular space and the meninges as well as in the parenchyma in MS lesions have been reported. We here summarize the current knowledge about T cells infiltrating the healthy and MS brain and argue that understanding the dynamics of physiological CNS surveillance by T cells is likely to improve the understanding of pathological conditions, such as MS.
AB - Circulating and tissue-resident T cells collaborate in the protection of tissues against harmful infections and malignant transformation but also can instigate autoimmune reactions. Similar roles for T cells in the brain have been less evident due to the compartmentized organization of the central nervous system (CNS). In recent years, beneficial as well as occasional, detrimental effects of T-cell-targeting drugs in people with early multiple sclerosis (MS) have increased interest in T cells patrolling the CNS. Next to studies focusing on T cells in the cerebrospinal fluid, phenotypic characteristics of T cells located in the perivascular space and the meninges as well as in the parenchyma in MS lesions have been reported. We here summarize the current knowledge about T cells infiltrating the healthy and MS brain and argue that understanding the dynamics of physiological CNS surveillance by T cells is likely to improve the understanding of pathological conditions, such as MS.
UR - http://www.scopus.com/inward/record.url?scp=85127610820&partnerID=8YFLogxK
U2 - 10.1007/s00281-022-00926-8
DO - 10.1007/s00281-022-00926-8
M3 - Review article
C2 - 35364699
AN - SCOPUS:85127610820
VL - 44
SP - 855
EP - 867
JO - Seminars in Immunopathology
JF - Seminars in Immunopathology
SN - 1863-2297
IS - 6
ER -