T1 Mapping in the Rat Myocardium at 7 Tesla Using a Modified CINE Inversion Recovery Sequence

H Smit, Ruben Pellicer Guridi, Jamal Guenoun, Dirk Poot, Gabriela Doeswijk, M Milanesi, Monique Bernsen, Gabriel Krestin, Stefan Klein, Gyula Kotek

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PurposeTo evaluate the reproducibility and sensitivity of the modified CINE inversion recovery (mCINE-IR) acquisition on rats for measuring the myocardial T1 at 7 Tesla. Materials and MethodsThe recently published mCINE-IR acquisition on humans was applied on rats for the first time, enabling the possibility of translational studies with an identical sequence. Simulations were used to study signal evolution and heart rate dependency. Gadolinium phantoms, a heart specimen and a healthy rat were used to study reproducibility. Two cryo-infarcted rats were scanned to measure late gadolinium enhancement (LGE). ResultsIn the phantom reproducibility studies the T1 measurements had a maximum coefficient of variation (COV) of 1.3%. For the in vivo reproducibility the COV was below 5% in the anterior cardiac segments. In simulations with phantoms and specimens, a heart rate dependency of approximately 0.5 ms/bpm was present. The T1 maps of the cryo-infarcted rats showed a clear lowering of T1 in de LGE region. ConclusionThe results show that mCINE-IR is highly reproducible and that the sensitivity allows detecting T1 changes in the rat myocardium. J. Magn. Reson. Imaging 2014;39:901-910. (c) 2013 Wiley Periodicals, Inc.
Original languageUndefined/Unknown
Pages (from-to)901-910
Number of pages10
JournalJournal of Magnetic Resonance Imaging
Issue number4
Publication statusPublished - 2014

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