Targeting the Microenvironment in Advanced Colorectal Cancer

Daniele V.F. Tauriello*, Eduard Batlle

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

82 Citations (Scopus)

Abstract

Colorectal cancer (CRC) diagnosis often occurs at late stages when tumor cells have already disseminated. Current therapies are poorly effective for metastatic disease, the main cause of death in CRC. Despite mounting evidence implicating the tumor microenvironment in CRC progression and metastasis, clinical practice remains predominantly focused on targeting the epithelial compartment. Because CRCs remain largely refractory to current therapies, we must devise alternative strategies. Transforming growth factor (TGF)-β has emerged as a key architect of the microenvironment in poor-prognosis cancers. Disseminated tumor cells show a strong dependency on a TGF-β-activated stroma during the establishment and subsequent expansion of metastasis. We review and discuss the development of integrated approaches focused on targeting the ecosystem of poor-prognosis CRCs.

Original languageEnglish
Pages (from-to)495-504
Number of pages10
JournalTrends in Cancer
Volume2
Issue number9
DOIs
Publication statusPublished - Sept 2016
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2016 Elsevier Inc.

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