TY - JOUR
T1 - Temporal changes of coronary artery plaque located behind the struts of the everolimus eluting bioresorbable vascular scaffold
AU - Brugaletta, S
AU - Garcia Garcia, Hector
AU - Garg, Scot
AU - Gomez Lara, Josep
AU - Diletti, Roberto
AU - Onuma, Yoshinobu
AU - van Geuns, Robert Jan
AU - McClean, D
AU - Dudek, D
AU - Thuesen, L
AU - Chevalier, B
AU - Windecker, S
AU - Whitbourn, R
AU - Dorange, C
AU - Miquel-Hebert, K
AU - Sudhir, K
AU - Ormiston, JA
AU - Serruys, PWJC (Patrick)
PY - 2011
Y1 - 2011
N2 - Implantation of a coronary stent results in a mechanical enlargement of the coronary lumen with stretching of the surrounding atherosclerotic plaque. Using intravascular ultrasound virtual-histology (IVUS-VH) we examined the temporal changes in composition of the plaque behind the struts (PBS) following the implantation of the everolimus eluting bioresorbable vascular scaffold (BVS). Using IVUS-VH and dedicated software, the composition of plaque was analyzed in all patients from the ABSORB B trial who were imaged with a commercially available IVUS-VH console (s5i system, Volcano Corporation, Rancho Cordova, CA, USA) post-treatment and at 6-month follow-up. This dedicated software enabled analysis of the PBS after subtraction of the VH signal generated by the struts. The presence of necrotic core (NC) in contact with the lumen was also evaluated at baseline and follow-up. IVUS-VH data, recorded with s5i system, were available at baseline and 6-month follow-up in 15 patients and demonstrated an increase in both the area of PBS (2.45 +/- A 1.93 mm(2) vs. 3.19 +/- A 2.48 mm(2), P = 0.005) and the external elastic membrane area (13.76 +/- A 4.07 mm(2) vs. 14.76 +/- A 4.56 mm(2), P = 0.006). Compared to baseline there was a significant progression in the NC (0.85 +/- A 0.70 mm(2) vs. 1.21 +/- A 0.92 mm(2), P = 0.010) and fibrous tissue area (0.88 +/- A 0.79 mm(2) vs. 1.15 +/- A 1.05 mm(2), P = 0.027) of the PBS. The NC in contact with the lumen in the treated segment did not increase with follow-up (7.33 vs. 6.36%, P = 0.2). Serial IVUS-VH analysis of BVS-treated lesions at 6-month demonstrated a progression in the NC and fibrous tissue content of PBS.
AB - Implantation of a coronary stent results in a mechanical enlargement of the coronary lumen with stretching of the surrounding atherosclerotic plaque. Using intravascular ultrasound virtual-histology (IVUS-VH) we examined the temporal changes in composition of the plaque behind the struts (PBS) following the implantation of the everolimus eluting bioresorbable vascular scaffold (BVS). Using IVUS-VH and dedicated software, the composition of plaque was analyzed in all patients from the ABSORB B trial who were imaged with a commercially available IVUS-VH console (s5i system, Volcano Corporation, Rancho Cordova, CA, USA) post-treatment and at 6-month follow-up. This dedicated software enabled analysis of the PBS after subtraction of the VH signal generated by the struts. The presence of necrotic core (NC) in contact with the lumen was also evaluated at baseline and follow-up. IVUS-VH data, recorded with s5i system, were available at baseline and 6-month follow-up in 15 patients and demonstrated an increase in both the area of PBS (2.45 +/- A 1.93 mm(2) vs. 3.19 +/- A 2.48 mm(2), P = 0.005) and the external elastic membrane area (13.76 +/- A 4.07 mm(2) vs. 14.76 +/- A 4.56 mm(2), P = 0.006). Compared to baseline there was a significant progression in the NC (0.85 +/- A 0.70 mm(2) vs. 1.21 +/- A 0.92 mm(2), P = 0.010) and fibrous tissue area (0.88 +/- A 0.79 mm(2) vs. 1.15 +/- A 1.05 mm(2), P = 0.027) of the PBS. The NC in contact with the lumen in the treated segment did not increase with follow-up (7.33 vs. 6.36%, P = 0.2). Serial IVUS-VH analysis of BVS-treated lesions at 6-month demonstrated a progression in the NC and fibrous tissue content of PBS.
U2 - 10.1007/s10554-010-9724-y
DO - 10.1007/s10554-010-9724-y
M3 - Article
C2 - 20941544
SN - 1569-5794
VL - 27
SP - 859
EP - 866
JO - International Journal of Cardiovascular Imaging
JF - International Journal of Cardiovascular Imaging
IS - 6
ER -