Temporary Treatment during Primary HIV Infection Does Not Affect Virologic Response to Subsequent Long-Term Treatment

ML Grijsen; FWNM Wit; S Jurriaans; FP Kroon; EF Schippers; P Koopmans; L Gras; JMA Lange; JM Prins

doi:10.1371/journal.pone.0089639

Temporary Treatment during Primary HIV Infection Does Not Affect Virologic Response to Subsequent Long-Term Treatment

ML Grijsen, FWNM Wit, S Jurriaans, FP Kroon, EF Schippers, P Koopmans, L Gras, JMA Lange, JM Prins

Research output: Contribution to journal › Article › Academic › peer-review

3 Citations (Scopus)

Abstract

Temporary cART during primary HIV-infection (PHI) did not select for drug resistance mutations after treatment interruption and did not affect the subsequent virological response to long-term cART. Our data demonstrate that fear of drug resistance development is not a valid argument to refrain from temporary early treatment during PHI.

Original language	Undefined/Unknown
Journal	PLoS One (print)
Volume	9
Issue number	4
DOIs	https://doi.org/10.1371/journal.pone.0089639
Publication status	Published - 2014
Externally published	Yes

Research programs

EMC MM-04-28-04

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1371/journal.pone.0089639

Cite this

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abstract = "Temporary cART during primary HIV-infection (PHI) did not select for drug resistance mutations after treatment interruption and did not affect the subsequent virological response to long-term cART. Our data demonstrate that fear of drug resistance development is not a valid argument to refrain from temporary early treatment during PHI.",

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AU - Grijsen, ML

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AU - Jurriaans, S

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AU - Schippers, EF

AU - Koopmans, P

AU - Gras, L

AU - Lange, JMA

AU - Prins, JM

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AB - Temporary cART during primary HIV-infection (PHI) did not select for drug resistance mutations after treatment interruption and did not affect the subsequent virological response to long-term cART. Our data demonstrate that fear of drug resistance development is not a valid argument to refrain from temporary early treatment during PHI.

U2 - 10.1371/journal.pone.0089639

DO - 10.1371/journal.pone.0089639

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