Ten-year all-cause death after percutaneous or surgical revascularization in diabetic patients with complex coronary artery disease

Rutao Wang, Patrick W. Serruys, Chao Gao, Hironori Hara, Kuniaki Takahashi, Masafumi Ono, Hideyuki Kawashima, Neil O'leary, David R. Holmes, Adam Witkowski, Nick Curzen, Francesco Burzotta, Stefan James, Robert Jan van Geuns, Arie Pieter Kappetein, Marie Angele Morel, Stuart J. Head, Daniel J.F.M. Thuijs, Piroze M. Davierwala, Timothy O'BrienValentin Fuster, Scot Garg, Yoshinobu Onuma

Research output: Contribution to journalArticleAcademicpeer-review

19 Citations (Scopus)
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Aims: The aim of this article was to compare rates of all-cause death at 10 years following coronary artery bypass grafting (CABG) or percutaneous coronary intervention (PCI) in patients with or without diabetes. Methods and results: The SYNTAXES study evaluated up to 10-year survival of 1800 patients with three-vessel disease (3VD) and/or left main coronary artery disease (LMCAD) randomized to receive either PCI or CABG in the SYNTAX trial. Ten-year all-cause death according to diabetic status and revascularization strategy was examined. In diabetics (n = 452), the risk of mortality was numerically higher with PCI compared with CABG at 5 years [19.6% vs. 13.3%, hazard ratio (HR): 1.53, 95% confidence interval (CI): 0.96, 2.43, P = 0.075], with the opposite seen between 5 and 10 years (PCI vs. CABG: 20.8% vs. 24.4%, HR: 0.82, 95% CI: 0.52, 1.27, P = 0.366). Irrespective of diabetic status, there was no significant difference in all-cause death at 10 years between patients receiving PCI or CABG, the absolute treatment difference was 1.9% in diabetics (PCI vs. CABG: 36.4% vs. 34.5%, difference: 1.9%, 95% CI: -7.6%, 11.1%, P = 0.551). Among insulin-treated patients (n = 182), all-cause death at 10 years was numerically higher with PCI (47.9% vs. 39.6%, difference: 8.2%, 95% CI: -6.5%, 22.5%, P = 0.227). Conclusions: The treatment effects of PCI vs. CABG on all-cause death at 10 years in patients with 3VD and/or LMCAD were similar irrespective of the presence of diabetes. There may, however, be a survival benefit with CABG in patients with insulin-treated diabetes. The association between revascularization strategy and very long-term ischaemic and safety outcomes for patients with diabetes needs further investigation in dedicated trials.

Original languageEnglish
Pages (from-to)56-67
Number of pages12
JournalEuropean Heart Journal
Issue number1
Early online date18 Aug 2021
Publication statusPublished - 1 Jan 2022

Bibliographical note

Funding Information:
The SYNTAX Extended Survival study was supported by the German Foundation of Heart Research (Frankfurt am Main, Germany). The SYNTAX trial was funded during 0-5 year follow-up by Boston Scientific Corporation (Marlborough, MA, USA). Both sponsors had no role in the study design, data collection, data analyses, and interpretation of the study data nor were involved in the decision to publish the final manuscript. The principal investigators and authors had complete scientific freedom. This work, R.W., and C.G. are supported by Science Foundation Research Professorship Award (15/RP/2765).

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