Th17 expansion in MS patients is counterbalanced by an expanded CD39 + regulatory T cell population during remission but not during relapse

Evelyn Peelen*, Jan Damoiseaux, Joost Smolders, Stephanie Knippenberg, Paul Menheere, Jan Willem Cohen Tervaert, Raymond Hupperts, Mariëlle Thewissen

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

44 Citations (Scopus)
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Abstract

In this study, percentages of CD39 + Treg and Th17 cells were compared between relapsing-remitting MS patients and controls and were related to the vitamin D status. The Th17 cell population was expanded in about 40% of the MS patients. In MS patients in remission, but not during relapse, a positive association was found between Th17 cell and CD39 + Treg percentages (r=0.468, p=0.007). Since CD39 + Tregs have been shown to have Th17 suppressive capacities, we propose that a dysregulated Th17/CD39 + Treg balance might contribute to disease exacerbation. A clear role for vitamin D in this regulation could not be established.

Original languageEnglish
Pages (from-to)97-103
Number of pages7
JournalJournal of Neuroimmunology
Volume240-241
DOIs
Publication statusPublished - 15 Dec 2011
Externally publishedYes

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