The Anterior Cingulate Cortex Predicts Future States to Mediate Model-Based Action Selection

T Akam, I Rodrigues-Vaz, Ivo Silva Marcelo, X Zhang, M Pereira, RF Oliveira, P Dayan, RM Costa

Research output: Contribution to journalArticleAcademicpeer-review

16 Citations (Scopus)

Abstract

Behavioral control is not unitary. It comprises parallel systems, model based and model free, that respectively generate flexible and habitual behaviors. Model-based decisions use predictions of the specific consequences of actions, but how these are implemented in the brain is poorly understood. We used calcium imaging and optogenetics in a sequential decision task for mice to show that the anterior cingulate cortex (ACC) predicts the state that actions will lead to, not simply whether they are good or bad, and monitors whether outcomes match these predictions. ACC represents the complete state space of the task, with reward signals that depend strongly on the state where reward is obtained but minimally on the preceding choice. Accordingly, ACC is necessary only for updating model-based strategies, not for basic reward-driven action reinforcement. These results reveal that ACC is a critical node in model-based control, with a specific role in predicting future states given chosen actions.

Original languageEnglish
Pages (from-to)149-163.e7
JournalNeuron
Volume109
Issue number1
DOIs
Publication statusPublished - 6 Jan 2021

Fingerprint

Dive into the research topics of 'The Anterior Cingulate Cortex Predicts Future States to Mediate Model-Based Action Selection'. Together they form a unique fingerprint.

Cite this