TY - JOUR
T1 - The ARCHITECT galectin-3 assay
T2 - Comparison with other automated and manual assays for the measurement of circulating galectin-3 levels in heart failure
AU - Meijers, Wouter C.
AU - Van Der Velde, A. Rogier
AU - De Boer, Rudolf A.
PY - 2014/4
Y1 - 2014/4
N2 - Heart failure (HF) is a common disease and affects millions of patients worldwide. Diagnosis, risk assessment and treatment of HF are difficult and therefore there is a need for additional tools to improve clinical performance. Biomarkers may be helpful in this respect. Galectin-3 is a relatively new biomarker that has been shown to have strong associations with the development of HF. Galectin-3 plays a role in inflammation and fibrosis, which are key elements in the pathophysiology of HF. Circulating plasma or serum galectin-3 levels have strong associations with the severity of HF and may be used to prognosticate or risk-stratify HF patients. Currently, there are several commercially available assays that can measure circulating galectin-3. This article describes the role galectin-3 plays in HF and its prognostic consequences. We will summarize the technical specifications of various manual and automated galectin-3 assays, which may help in HF management.
AB - Heart failure (HF) is a common disease and affects millions of patients worldwide. Diagnosis, risk assessment and treatment of HF are difficult and therefore there is a need for additional tools to improve clinical performance. Biomarkers may be helpful in this respect. Galectin-3 is a relatively new biomarker that has been shown to have strong associations with the development of HF. Galectin-3 plays a role in inflammation and fibrosis, which are key elements in the pathophysiology of HF. Circulating plasma or serum galectin-3 levels have strong associations with the severity of HF and may be used to prognosticate or risk-stratify HF patients. Currently, there are several commercially available assays that can measure circulating galectin-3. This article describes the role galectin-3 plays in HF and its prognostic consequences. We will summarize the technical specifications of various manual and automated galectin-3 assays, which may help in HF management.
UR - http://www.scopus.com/inward/record.url?scp=84896902187&partnerID=8YFLogxK
U2 - 10.1586/14737159.2014.892421
DO - 10.1586/14737159.2014.892421
M3 - Article
C2 - 24606321
AN - SCOPUS:84896902187
SN - 1473-7159
VL - 14
SP - 257
EP - 266
JO - Expert Review of Molecular Diagnostics
JF - Expert Review of Molecular Diagnostics
IS - 3
ER -