The Authors' Reply: Organoid Technology: Are Human Cholangiocyte Organoids Immune Protected?

We thank Ekser et al for reading our commentary on the groundbreaking Science publication by Sampaziotis et al on repair of bile ducts after transplantation of cholangiocyte organoids in human liver grafts. Ekser et al comment that if allogenic cholangiocyte organoids would be used for graft repair, this potentially can provoke an alloimmune response. The authors are “puzzled by the outcome of the original paper as nonautologous organoids were used and no protective immunosuppressive medication is used during the normothermic machine perfusion of the liver grafts.” [...]