The Benefit of Complete Response to Treatment in Patients With Chronic Spontaneous Urticaria—CURE Results

Pavel Kolkhir, Pedro A. Laires, Pascale Salameh, Riccardo Asero, Mojca Bizjak, Mitja Košnik, Joachim Dissemond, Martijn van Doorn, Tomasz Hawro, Alicja Kasperska-Zajac, Magdalena Zajac, Emek Kocatürk, Jonny Peter, Claudio A.S. Parisi, Carla A. Ritchie, Kanokvalai Kulthanan, Papapit Tuchinda, Daria Fomina, Elena Kovalkova, Maryam KhoshkhuiSamaneh Kouzegaran, Niki Papapostolou, Aurélie Du-Thanh, Akiko Kamegashira, Raisa Meshkova, Alexander Vitchuk, Andrea Bauer, Clive Grattan, Petra Staubach, Laurence Bouillet, Ana M. Giménez-Arnau, Marcus Maurer, Karsten Weller*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)


Background and Objective: Chronic spontaneous urticaria (CSU) is a distressing disease. We report real-world data from the global Chronic Urticaria Registry (CURE) about associations between various CSU states and sleep impairment, plus important health-related quality-of-life (HRQoL) outcomes and compared different methods to assess CSU states. Methods: CURE data were collected at baseline and 6-monthly follow-ups (FU). Assessments included CSU states using the Urticaria Control Test (UCT), weekly Urticaria Activity Score (UAS7), and Physician Global Assessment (PhyGA) of treatment response. Complete response to treatment (CR, UAS7 = 0), complete control of disease (CC, UCT = 16), and PhyGA = CR were assessed, plus the Dermatology Life Quality Index and the Chronic Urticaria Quality-of-Life Questionnaire (CU-Q2oL) sleep domain. Results: Overall, 2078 patients were included. At baseline, 9.8%, 17.9%, and 42.3% of patients had UCT = 16, UAS7 = 0, or PhyGA = CR, respectively, which increased at FU1 and FU2. Patients with higher UCT scores had better sleep and HRQoL. The presence of angioedema without wheals, episodic disease, omalizumab treatment, and male sex were associated with CC (P <.05). Among 469 patients who achieved CC or CR, 16.4% (n = 77) showed CC or CR with all 3 instruments. Agreement between UCT = 16 and UAS7 = 0 measurements was moderate (κ = 0.581), but poor between UCT = 16 and PhyGA = CR (κ = 0.208). Conclusions: Few patients had CR/CC of their CSU at baseline entry. Disease control strongly related to good sleep and better HRQoL; therefore, it is important to aim for CR in CSU treatment. Patient-reported UCT and UAS7 assessments demonstrated a more accurate measurement of CSU state versus physician assessments.

Original languageEnglish
Pages (from-to)610-620.e5
JournalJournal of Allergy and Clinical Immunology: In Practice
Issue number2
Publication statusPublished - Feb 2023

Bibliographical note

Funding Information:
Chronic Urticaria Registry (CURE) has been funded by the Urticaria Network e.V. (a German nonprofit organization), the European Academy of Dermatology and Venereology (proposal number 2014-013), Novartis, and Uriach. Sponsors have not been involved in the design or implementation of CURE.

Publisher Copyright:
© 2022


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