The cause and course of acquired demyelinating syndromes: Focus on pediatric-onset MS and antibody-associated disorders

Research output: Types of ThesisDoctoral ThesisInternal

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Abstract

Acquired demyelinating syndromes (ADS) encompass a wide and constantly evolving spectrum of monophasic and relapsing potentially disabling immune-mediated
disorders of the central nervous system. Due to overlapping features, determination of
specific ADS subtype with prediction of following disease course may be challenging,
especially at onset of disease. However, this is crucial for early and adequate patient
management. In addition, this uncertainty regarding diagnosis and prognosis is often
the main burden for patients and their families. Therefore, this thesis focuses on the
cause and course of pediatric-onset multiple sclerosis and other ADS in childhood
in part I, and antibody-associated ADS in children and adults in part II. We aimed
to increase the understanding of pathophysiology and prognosis of the different
ADS, to add to an earlier and more accurate delineation of the distinctive disorders
included under the umbrella term ADS.
Original languageEnglish
Awarding Institution
  • Erasmus University Rotterdam
Supervisors/Advisors
  • Sillevis Smitt, Peter, Supervisor
  • Neuteboom, Rinze, Co-supervisor
Award date24 Jan 2023
Place of PublicationRotterdam
Print ISBNs978-94-6469-063-7
Publication statusPublished - 24 Jan 2023

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