The clinical use of drugs influencing neurotransmitters in the brain to promote motor recovery after stroke: a Cochrane systematic review

H. I. Berends*, J. M.M. Nijlant, K. L.L. Movig, M. J.A.M. Van Putten, M. J.A. Jannink, M. J. Ijzerman

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

37 Citations (Scopus)

Abstract

The objective of tills review was to compare and to discuss the results of studies that investigated the ability of drugs to improve motor recovery after stroke by influencing dopamine, norepinephrine, or serotonin concentrations in the brain. A systematic literature search up to January 2009 was conducted in MEDLINE, Pubmed, EMBASE and in the database of the Cochrane Stroke Group Trial Register. In addition, the literature reference lists of the relevant publications were checked. The literature search was conducted in order to identify randomized controlled trials focusing on the effects of drugs on motor recovery after stroke. In order to structure the data, motor recovery was sub-divided into motor control and motor function. The methodological quality of the studies was also assessed. Six studies, investigating the effects of 7 different kinds of drugs were included. Methodological scores varied between 10 and 14 (max 19). Motor control was not influenced by any of the drugs. Motor function improved in patients treated with methylphenidate, trazodone, and nortriptyline. Results for fluoxetine and levodopa were contradicting. There is insufficient evidence to conclude that neuromodulating drugs targeting serotonin, norepinephrine, or dopamine influence motor recovery after stroke.

Original languageEnglish
Pages (from-to)621-630
Number of pages10
JournalEuropean Journal of Physical and Rehabilitation Medicine
Volume45
Issue number4
Publication statusPublished - Dec 2009
Externally publishedYes

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