The contribution of HPV18 to cervical cancer is underestimated using high-grade CIN as a measure of screening efficiency

S. Bulk; J. Berkhof; L. Rozendaal; N. C.Fransen Daalmeijer; M. Gök; F. A. De Schipper; F. J. Van Kemenade; P. J.F. Snijders; C. J.L.M. Meijer

doi:10.1038/sj.bjc.6603693

The contribution of HPV18 to cervical cancer is underestimated using high-grade CIN as a measure of screening efficiency

S. Bulk
, J. Berkhof
, L. Rozendaal
, N. C.Fransen Daalmeijer
, M. Gök
, F. A. De Schipper
, F. J. Van Kemenade
, P. J.F. Snijders
, C. J.L.M. Meijer^*

^*Corresponding author for this work

VU University Medical Center
Ziekenhuis Walcheren

Research output: Contribution to journal › Article › Academic › peer-review

22 Citations (Scopus)

3 Downloads (Pure)

Abstract

In one geographical area, 14 high-risk human papillomavirus types in cervical intraepithelial neoplasia (CIN2/3; n=139) and cervical squamous cell carcinoma (SCC; n=84) were analysed. HPV18 was more prevalent in SCC than CIN2/3 (OR 9.8; 95% confidence interval: 2.5-39). Other high-risk types prevalences corresponded in CIN2/3 and SCC. Evaluations using CIN2/3 as a measure of efficiency underestimate the contribution of HPV18 to SCC.

Original language	English
Pages (from-to)	1234-1236
Number of pages	3
Journal	British Journal of Cancer
Volume	96
Issue number	8
DOIs	https://doi.org/10.1038/sj.bjc.6603693
Publication status	Published - 23 Apr 2007
Externally published	Yes

Bibliographical note

Funding Information:
This study was supported by grants 28-2831 and 2200.0089 from the Health Research and Development Council of the Netherlands (ZonMw). The study was approved by the Medical Ethics Committee of the VU University Medical Center, Amsterdam, The Netherlands (2001/179)This study was supported by grants 28-2831 and 2200.0089 from the Health Research & Development Council of the Netherlands (ZonMw).S. Bulk performed the analyses and wrote the manuscript. J Berkhof was responsible for the statistical methods. PJF Snijders and CJLM Meijer were responsible for the virology determinations. J Berkhof and CJLM Meijer were responsible for the study design. All investigators discussed findings and critically revised the paper.

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The contribution of HPV18 to cervical cancer is underestimated using high-grade CIN as a measure of screening efficiencyFinal published version, 93.9 KBLicence: Unspecified

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title = "The contribution of HPV18 to cervical cancer is underestimated using high-grade CIN as a measure of screening efficiency",

abstract = "In one geographical area, 14 high-risk human papillomavirus types in cervical intraepithelial neoplasia (CIN2/3; n=139) and cervical squamous cell carcinoma (SCC; n=84) were analysed. HPV18 was more prevalent in SCC than CIN2/3 (OR 9.8; 95\% confidence interval: 2.5-39). Other high-risk types prevalences corresponded in CIN2/3 and SCC. Evaluations using CIN2/3 as a measure of efficiency underestimate the contribution of HPV18 to SCC.",

author = "S. Bulk and J. Berkhof and L. Rozendaal and Daalmeijer, \{N. C.Fransen\} and M. G{\"o}k and \{De Schipper\}, \{F. A.\} and \{Van Kemenade\}, \{F. J.\} and Snijders, \{P. J.F.\} and Meijer, \{C. J.L.M.\}",

note = "Funding Information: This study was supported by grants 28-2831 and 2200.0089 from the Health Research and Development Council of the Netherlands (ZonMw). The study was approved by the Medical Ethics Committee of the VU University Medical Center, Amsterdam, The Netherlands (2001/179)This study was supported by grants 28-2831 and 2200.0089 from the Health Research \& Development Council of the Netherlands (ZonMw).S. Bulk performed the analyses and wrote the manuscript. J Berkhof was responsible for the statistical methods. PJF Snijders and CJLM Meijer were responsible for the virology determinations. J Berkhof and CJLM Meijer were responsible for the study design. All investigators discussed findings and critically revised the paper.",

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T1 - The contribution of HPV18 to cervical cancer is underestimated using high-grade CIN as a measure of screening efficiency

AU - Bulk, S.

AU - Berkhof, J.

AU - Rozendaal, L.

AU - Daalmeijer, N. C.Fransen

AU - Gök, M.

AU - De Schipper, F. A.

AU - Van Kemenade, F. J.

AU - Snijders, P. J.F.

AU - Meijer, C. J.L.M.

N1 - Funding Information: This study was supported by grants 28-2831 and 2200.0089 from the Health Research and Development Council of the Netherlands (ZonMw). The study was approved by the Medical Ethics Committee of the VU University Medical Center, Amsterdam, The Netherlands (2001/179)This study was supported by grants 28-2831 and 2200.0089 from the Health Research & Development Council of the Netherlands (ZonMw).S. Bulk performed the analyses and wrote the manuscript. J Berkhof was responsible for the statistical methods. PJF Snijders and CJLM Meijer were responsible for the virology determinations. J Berkhof and CJLM Meijer were responsible for the study design. All investigators discussed findings and critically revised the paper.

PY - 2007/4/23

Y1 - 2007/4/23

N2 - In one geographical area, 14 high-risk human papillomavirus types in cervical intraepithelial neoplasia (CIN2/3; n=139) and cervical squamous cell carcinoma (SCC; n=84) were analysed. HPV18 was more prevalent in SCC than CIN2/3 (OR 9.8; 95% confidence interval: 2.5-39). Other high-risk types prevalences corresponded in CIN2/3 and SCC. Evaluations using CIN2/3 as a measure of efficiency underestimate the contribution of HPV18 to SCC.

AB - In one geographical area, 14 high-risk human papillomavirus types in cervical intraepithelial neoplasia (CIN2/3; n=139) and cervical squamous cell carcinoma (SCC; n=84) were analysed. HPV18 was more prevalent in SCC than CIN2/3 (OR 9.8; 95% confidence interval: 2.5-39). Other high-risk types prevalences corresponded in CIN2/3 and SCC. Evaluations using CIN2/3 as a measure of efficiency underestimate the contribution of HPV18 to SCC.

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SN - 0007-0920

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JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 8

ER -

The contribution of HPV18 to cervical cancer is underestimated using high-grade CIN as a measure of screening efficiency

Abstract

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