The course of health-related quality of life in the first 2 years after a diagnosis of head and neck cancer: the role of personal, clinical, psychological, physical, social, lifestyle, disease-related, and biological factors

Irma M. Verdonck-de Leeuw; Laura H.A. Korsten; Annette van Nieuwenhuizen; Rob J. Baatenburg de Jong; Ruud H. Brakenhoff; Laurien M. Buffart; Femke Lamers; Johannes A. Langendijk; C. René Leemans; Jan H. Smit; Mirjam A. Sprangers; Robert P. Takes; Chris H.J. Terhaard; Birgit I. Lissenberg-Witte; Femke Jansen

doi:10.1007/s00520-023-07918-w

The course of health-related quality of life in the first 2 years after a diagnosis of head and neck cancer: the role of personal, clinical, psychological, physical, social, lifestyle, disease-related, and biological factors

Irma M. Verdonck-de Leeuw^*
, Laura H.A. Korsten
, Annette van Nieuwenhuizen
, Rob J. Baatenburg de Jong
, Ruud H. Brakenhoff
, Laurien M. Buffart
, Femke Lamers
, Johannes A. Langendijk
, C. René Leemans
, Jan H. Smit
, Mirjam A. Sprangers
, Robert P. Takes
, Chris H.J. Terhaard
, Birgit I. Lissenberg-Witte
, Femke Jansen

^*Corresponding author for this work

Otorhinolaryngology and Head and Neck Surgery

Vrije Universiteit Amsterdam
Amsterdam UMC
Amsterdam Public Health Research Institute
University Medical Centre Groningen
University of Amsterdam
Radboud University Medical Center
Utrecht University

Research output: Contribution to journal › Article › Academic › peer-review

10 Citations (Scopus)

24 Downloads (Pure)

Abstract

Purpose: The aim of this prospective cohort study was to estimate the relationship between the course of HRQOL in the first 2 years after diagnosis and treatment of head and neck cancer (HNC) and personal, clinical, psychological, physical, social, lifestyle, HNC-related, and biological factors. Methods: Data were used from 638 HNC patients of the NETherlands QUality of life and BIomedical Cohort study (NET-QUBIC). Linear mixed models were used to investigate factors associated with the course of HRQOL (EORTC QLQ-C30 global quality of life (QL) and summary score (SumSc)) from baseline to 3, 6, 12, and 24 months after treatment. Results: Baseline depressive symptoms, social contacts, and oral pain were significantly associated with the course of QL from baseline to 24 months. Tumor subsite and baseline social eating, stress (hyperarousal), coughing, feeling ill, and IL-10 were associated with the course of SumSc. Post-treatment social contacts and stress (avoidance) were significantly associated with the course of QL from 6 to 24 months, and social contacts and weight loss with the course of SumSc. The course of SumSc from 6 to 24 months was also significantly associated with a change in financial problems, speech problems, weight loss, and shoulder problems between baseline and 6 months. Conclusion: Baseline clinical, psychological, social, lifestyle, HNC-related, and biological factors are associated with the course of HRQOL from baseline to 24 months after treatment. Post-treatment social, lifestyle, and HNC-related factors are associated with the course of HRQOL from 6 to 24 months after treatment.

Original language	English
Article number	458
Journal	Supportive Care in Cancer
Volume	31
Issue number	8
DOIs	https://doi.org/10.1007/s00520-023-07918-w
Publication status	Published - 11 Jul 2023

Bibliographical note

Funding Information:
This study was carried out using the research infrastructure within the NETherlands QUality of life and BIomedical Cohort study in head and neck cancer (NET-QUBIC) project funded by the Dutch Cancer Society (grant number VU 2013-5930). The funding body had no role in the study design, the data collection, analysis, and interpretation, nor the manuscript preparation.

Publisher Copyright: © 2023, The Author(s).

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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Verdonck-de Leeuw, I. M., Korsten, L. H. A., van Nieuwenhuizen, A., Baatenburg de Jong, R. J., Brakenhoff, R. H., Buffart, L. M., Lamers, F., Langendijk, J. A., Leemans, C. R., Smit, J. H., Sprangers, M. A., Takes, R. P., Terhaard, C. H. J., Lissenberg-Witte, B. I., & Jansen, F. (2023). The course of health-related quality of life in the first 2 years after a diagnosis of head and neck cancer: the role of personal, clinical, psychological, physical, social, lifestyle, disease-related, and biological factors. Supportive Care in Cancer, 31(8), Article 458. https://doi.org/10.1007/s00520-023-07918-w

@article{1a04218eca354fab9837f80625afd057,

title = "The course of health-related quality of life in the first 2 years after a diagnosis of head and neck cancer: the role of personal, clinical, psychological, physical, social, lifestyle, disease-related, and biological factors",

abstract = "Purpose: The aim of this prospective cohort study was to estimate the relationship between the course of HRQOL in the first 2 years after diagnosis and treatment of head and neck cancer (HNC) and personal, clinical, psychological, physical, social, lifestyle, HNC-related, and biological factors. Methods: Data were used from 638 HNC patients of the NETherlands QUality of life and BIomedical Cohort study (NET-QUBIC). Linear mixed models were used to investigate factors associated with the course of HRQOL (EORTC QLQ-C30 global quality of life (QL) and summary score (SumSc)) from baseline to 3, 6, 12, and 24 months after treatment. Results: Baseline depressive symptoms, social contacts, and oral pain were significantly associated with the course of QL from baseline to 24 months. Tumor subsite and baseline social eating, stress (hyperarousal), coughing, feeling ill, and IL-10 were associated with the course of SumSc. Post-treatment social contacts and stress (avoidance) were significantly associated with the course of QL from 6 to 24 months, and social contacts and weight loss with the course of SumSc. The course of SumSc from 6 to 24 months was also significantly associated with a change in financial problems, speech problems, weight loss, and shoulder problems between baseline and 6 months. Conclusion: Baseline clinical, psychological, social, lifestyle, HNC-related, and biological factors are associated with the course of HRQOL from baseline to 24 months after treatment. Post-treatment social, lifestyle, and HNC-related factors are associated with the course of HRQOL from 6 to 24 months after treatment.",

author = "\{Verdonck-de Leeuw\}, \{Irma M.\} and Korsten, \{Laura H.A.\} and \{van Nieuwenhuizen\}, Annette and \{Baatenburg de Jong\}, \{Rob J.\} and Brakenhoff, \{Ruud H.\} and Buffart, \{Laurien M.\} and Femke Lamers and Langendijk, \{Johannes A.\} and Leemans, \{C. Ren{\'e}\} and Smit, \{Jan H.\} and Sprangers, \{Mirjam A.\} and Takes, \{Robert P.\} and Terhaard, \{Chris H.J.\} and Lissenberg-Witte, \{Birgit I.\} and Femke Jansen",

note = "Funding Information: This study was carried out using the research infrastructure within the NETherlands QUality of life and BIomedical Cohort study in head and neck cancer (NET-QUBIC) project funded by the Dutch Cancer Society (grant number VU 2013-5930). The funding body had no role in the study design, the data collection, analysis, and interpretation, nor the manuscript preparation. Publisher Copyright: {\textcopyright} 2023, The Author(s).",

year = "2023",

month = jul,

day = "11",

doi = "10.1007/s00520-023-07918-w",

language = "English",

volume = "31",

journal = "Supportive Care in Cancer",

issn = "0941-4355",

publisher = "Springer Science+Business Media",

number = "8",

}

Verdonck-de Leeuw, IM, Korsten, LHA, van Nieuwenhuizen, A, Baatenburg de Jong, RJ, Brakenhoff, RH, Buffart, LM, Lamers, F, Langendijk, JA, Leemans, CR, Smit, JH, Sprangers, MA, Takes, RP, Terhaard, CHJ, Lissenberg-Witte, BI & Jansen, F 2023, 'The course of health-related quality of life in the first 2 years after a diagnosis of head and neck cancer: the role of personal, clinical, psychological, physical, social, lifestyle, disease-related, and biological factors', Supportive Care in Cancer, vol. 31, no. 8, 458. https://doi.org/10.1007/s00520-023-07918-w

The course of health-related quality of life in the first 2 years after a diagnosis of head and neck cancer: the role of personal, clinical, psychological, physical, social, lifestyle, disease-related, and biological factors. / Verdonck-de Leeuw, Irma M.; Korsten, Laura H.A.; van Nieuwenhuizen, Annette et al.
In: Supportive Care in Cancer, Vol. 31, No. 8, 458, 11.07.2023.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - The course of health-related quality of life in the first 2 years after a diagnosis of head and neck cancer

T2 - the role of personal, clinical, psychological, physical, social, lifestyle, disease-related, and biological factors

AU - Verdonck-de Leeuw, Irma M.

AU - Korsten, Laura H.A.

AU - van Nieuwenhuizen, Annette

AU - Baatenburg de Jong, Rob J.

AU - Brakenhoff, Ruud H.

AU - Buffart, Laurien M.

AU - Lamers, Femke

AU - Langendijk, Johannes A.

AU - Leemans, C. René

AU - Smit, Jan H.

AU - Sprangers, Mirjam A.

AU - Takes, Robert P.

AU - Terhaard, Chris H.J.

AU - Lissenberg-Witte, Birgit I.

AU - Jansen, Femke

N1 - Funding Information: This study was carried out using the research infrastructure within the NETherlands QUality of life and BIomedical Cohort study in head and neck cancer (NET-QUBIC) project funded by the Dutch Cancer Society (grant number VU 2013-5930). The funding body had no role in the study design, the data collection, analysis, and interpretation, nor the manuscript preparation. Publisher Copyright: © 2023, The Author(s).

PY - 2023/7/11

Y1 - 2023/7/11

N2 - Purpose: The aim of this prospective cohort study was to estimate the relationship between the course of HRQOL in the first 2 years after diagnosis and treatment of head and neck cancer (HNC) and personal, clinical, psychological, physical, social, lifestyle, HNC-related, and biological factors. Methods: Data were used from 638 HNC patients of the NETherlands QUality of life and BIomedical Cohort study (NET-QUBIC). Linear mixed models were used to investigate factors associated with the course of HRQOL (EORTC QLQ-C30 global quality of life (QL) and summary score (SumSc)) from baseline to 3, 6, 12, and 24 months after treatment. Results: Baseline depressive symptoms, social contacts, and oral pain were significantly associated with the course of QL from baseline to 24 months. Tumor subsite and baseline social eating, stress (hyperarousal), coughing, feeling ill, and IL-10 were associated with the course of SumSc. Post-treatment social contacts and stress (avoidance) were significantly associated with the course of QL from 6 to 24 months, and social contacts and weight loss with the course of SumSc. The course of SumSc from 6 to 24 months was also significantly associated with a change in financial problems, speech problems, weight loss, and shoulder problems between baseline and 6 months. Conclusion: Baseline clinical, psychological, social, lifestyle, HNC-related, and biological factors are associated with the course of HRQOL from baseline to 24 months after treatment. Post-treatment social, lifestyle, and HNC-related factors are associated with the course of HRQOL from 6 to 24 months after treatment.

AB - Purpose: The aim of this prospective cohort study was to estimate the relationship between the course of HRQOL in the first 2 years after diagnosis and treatment of head and neck cancer (HNC) and personal, clinical, psychological, physical, social, lifestyle, HNC-related, and biological factors. Methods: Data were used from 638 HNC patients of the NETherlands QUality of life and BIomedical Cohort study (NET-QUBIC). Linear mixed models were used to investigate factors associated with the course of HRQOL (EORTC QLQ-C30 global quality of life (QL) and summary score (SumSc)) from baseline to 3, 6, 12, and 24 months after treatment. Results: Baseline depressive symptoms, social contacts, and oral pain were significantly associated with the course of QL from baseline to 24 months. Tumor subsite and baseline social eating, stress (hyperarousal), coughing, feeling ill, and IL-10 were associated with the course of SumSc. Post-treatment social contacts and stress (avoidance) were significantly associated with the course of QL from 6 to 24 months, and social contacts and weight loss with the course of SumSc. The course of SumSc from 6 to 24 months was also significantly associated with a change in financial problems, speech problems, weight loss, and shoulder problems between baseline and 6 months. Conclusion: Baseline clinical, psychological, social, lifestyle, HNC-related, and biological factors are associated with the course of HRQOL from baseline to 24 months after treatment. Post-treatment social, lifestyle, and HNC-related factors are associated with the course of HRQOL from 6 to 24 months after treatment.

UR - https://www.scopus.com/pages/publications/85164292245

U2 - 10.1007/s00520-023-07918-w

DO - 10.1007/s00520-023-07918-w

M3 - Article

C2 - 37432446

AN - SCOPUS:85164292245

SN - 0941-4355

VL - 31

JO - Supportive Care in Cancer

JF - Supportive Care in Cancer

IS - 8

M1 - 458

ER -

Verdonck-de Leeuw IM, Korsten LHA, van Nieuwenhuizen A, Baatenburg de Jong RJ, Brakenhoff RH, Buffart LM et al. The course of health-related quality of life in the first 2 years after a diagnosis of head and neck cancer: the role of personal, clinical, psychological, physical, social, lifestyle, disease-related, and biological factors. Supportive Care in Cancer. 2023 Jul 11;31(8):458. doi: 10.1007/s00520-023-07918-w

The course of health-related quality of life in the first 2 years after a diagnosis of head and neck cancer: the role of personal, clinical, psychological, physical, social, lifestyle, disease-related, and biological factors

Abstract

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