The Cryptochromes: Blue Light Photoreceptors in Plants and Animals

I Chaves, R Pokorny, M Byrdin, N Hoang, T Ritz, K Brettel, LO Essen, Bert van der Horst, A Batschauer, M Ahmad

Research output: Contribution to journalArticleAcademic

583 Citations (Scopus)

Abstract

Cryptochromes are flavoprotein photoreceptors first identified in Arabidopsis thaliana, where they play key roles in growth and development. Subsequently identified in prokaryotes, archaea, and many eukaryotes, cryptochromes function in the animal circadian clock and are proposed as magnetoreceptors in migratory birds. Cryptochromes are closely structurally related to photolyases, evolutionarily ancient flavoproteins that catalyze light-dependent DNA repair. Here, we review the structural, photochemical, and molecular properties of cry-DASH, plant, and animal cryptochromes in relation to biological signaling mechanisms and uncover common features that may contribute to better understanding the function of cryptochromes in diverse systems including in man.
Original languageUndefined/Unknown
Pages (from-to)335-364
Number of pages30
JournalAnnual Review of Plant Biology, vol 62
Volume62
DOIs
Publication statusPublished - 2011

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