The DOT1L inhibitor pinometostat reduces H3K79 methylation and has modest clinical activity in adult acute leukemia

EM Stein; G Garcia-Manero; DA Rizzieri; R Tibes; JG Berdeja; MR Savona; Mojca Jongen - Lavrencic; JK Altman; B Thomson; SJ Blakemore; SR Daigle; NJ Waters; AB Suttle; A Clawson; R Pollock; A Krivtsov; SA Armstrong; J DiMartino; E Hedrick; Bob Löwenberg; MS Tallman

doi:10.1182/blood-2017-12-818948

The DOT1L inhibitor pinometostat reduces H3K79 methylation and has modest clinical activity in adult acute leukemia

EM Stein, G Garcia-Manero, DA Rizzieri, R Tibes, JG Berdeja, MR Savona, Mojca Jongen - Lavrencic, JK Altman, B Thomson, SJ Blakemore, SR Daigle, NJ Waters, AB Suttle, A Clawson, R Pollock, A Krivtsov, SA Armstrong, J DiMartino, E Hedrick, Bob LöwenbergMS Tallman

Hematology

Research output: Contribution to journal › Article › Academic › peer-review

229 Citations (Scopus)

Original language	Undefined/Unknown
Pages (from-to)	2661-2669
Number of pages	9
Journal	Blood
Volume	131
Issue number	24
DOIs	https://doi.org/10.1182/blood-2017-12-818948
Publication status	Published - 2018

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10.1182/blood-2017-12-818948

http://hdl.handle.net/1765/108946

Cite this

Stein, EM., Garcia-Manero, G., Rizzieri, DA., Tibes, R., Berdeja, JG., Savona, MR., Jongen - Lavrencic, M., Altman, JK., Thomson, B., Blakemore, SJ., Daigle, SR., Waters, NJ., Suttle, AB., Clawson, A., Pollock, R., Krivtsov, A., Armstrong, SA., DiMartino, J., Hedrick, E., ... Tallman, MS. (2018). The DOT1L inhibitor pinometostat reduces H3K79 methylation and has modest clinical activity in adult acute leukemia. Blood, 131(24), 2661-2669. https://doi.org/10.1182/blood-2017-12-818948

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title = "The DOT1L inhibitor pinometostat reduces H3K79 methylation and has modest clinical activity in adult acute leukemia",

author = "EM Stein and G Garcia-Manero and DA Rizzieri and R Tibes and JG Berdeja and MR Savona and {Jongen - Lavrencic}, Mojca and JK Altman and B Thomson and SJ Blakemore and SR Daigle and NJ Waters and AB Suttle and A Clawson and R Pollock and A Krivtsov and SA Armstrong and J DiMartino and E Hedrick and Bob L{\"o}wenberg and MS Tallman",

year = "2018",

doi = "10.1182/blood-2017-12-818948",

language = "Undefined/Unknown",

volume = "131",

pages = "2661--2669",

journal = "Blood",

issn = "0006-4971",

publisher = "American Society of Hematology",

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Stein, EM, Garcia-Manero, G, Rizzieri, DA, Tibes, R, Berdeja, JG, Savona, MR, Jongen - Lavrencic, M, Altman, JK, Thomson, B, Blakemore, SJ, Daigle, SR, Waters, NJ, Suttle, AB, Clawson, A, Pollock, R, Krivtsov, A, Armstrong, SA, DiMartino, J, Hedrick, E, Löwenberg, B & Tallman, MS 2018, 'The DOT1L inhibitor pinometostat reduces H3K79 methylation and has modest clinical activity in adult acute leukemia', Blood, vol. 131, no. 24, pp. 2661-2669. https://doi.org/10.1182/blood-2017-12-818948

TY - JOUR

T1 - The DOT1L inhibitor pinometostat reduces H3K79 methylation and has modest clinical activity in adult acute leukemia

AU - Stein, EM

AU - Garcia-Manero, G

AU - Rizzieri, DA

AU - Tibes, R

AU - Berdeja, JG

AU - Savona, MR

AU - Jongen - Lavrencic, Mojca

AU - Altman, JK

AU - Thomson, B

AU - Blakemore, SJ

AU - Daigle, SR

AU - Waters, NJ

AU - Suttle, AB

AU - Clawson, A

AU - Pollock, R

AU - Krivtsov, A

AU - Armstrong, SA

AU - DiMartino, J

AU - Hedrick, E

AU - Löwenberg, Bob

AU - Tallman, MS

PY - 2018

Y1 - 2018

U2 - 10.1182/blood-2017-12-818948

DO - 10.1182/blood-2017-12-818948

M3 - Article

SN - 0006-4971

VL - 131

SP - 2661

EP - 2669

JO - Blood

JF - Blood

IS - 24

ER -