The effect of anticholinergic agents on gastro-oesophageal reflux and related disorders

Eva Soest, Jeanne Dieleman, Ernst Kuipers

Research output: Contribution to journalArticleAcademicpeer-review

10 Citations (Scopus)


The most important risk factor of oesophageal adenocarcinoma is gastro-oesophageal reflux disease. Gastro-oesophageal reflux disease is in itself a common disorder, giving bothersome symptoms. in daily clinical practice, anticholinergic drugs are believed to increase the risk of gastro-oesophageal reflux through effects on the lower oesophageal sphincter. in this review we discuss the available literature on the potential association between the use of drugs with anticholinergic properties and the risk of gastro-oesophageal reflux-related disorders.
Original languageUndefined/Unknown
Pages (from-to)173-180
Number of pages8
JournalExpert Opinion on Drug Safety
Issue number2
Publication statusPublished - 2008

Research programs

  • EMC MM-04-20-01
  • EMC NIHES-03-77-02

Cite this