TY - JOUR
T1 - The effect of donor body mass index on graft function in liver transplantation
T2 - A systematic review
AU - Takagi, Kosei
AU - de Wilde, Roeland
AU - Polak, Wojtek
AU - IJzermans, J.N.M.
PY - 2020/10
Y1 - 2020/10
N2 - The impact of donor body mass index (BMI) on graft function outcomes in liver transplantation (LT) is still controversial. The aim of this study was to review the current evidence investigating the effect of donor BMI on outcomes in patients undergoing LT. A systematic review was performed to evaluate relevant outcomes such as the availability of data on donor BMI as well as graft and patient survival after LT. Screening of 901 articles resulted in 11 observational studies for data extraction. In adult deceased donor after brain death and living donor LT, donor BMI was not associatedwith graft and patient survival. However, high donor BMIwas associated with a higher chance of macrosteatosis besides a significantly higher incidence of declined livers. In pediatric LT, severe obesity in adult donors with BMI >= 35 was associated with graft loss and mortality, whereas obesity in pediatric donors was not associated with graft loss and mortality. Accordingly, donor BMI is not associated with long-term outcomes in adult patients undergoing LT. However, further research should be conducted to identify the effect of donor BMI on outcomes in LT. (C) 2020 The Author(s). Published by Elsevier Inc.
AB - The impact of donor body mass index (BMI) on graft function outcomes in liver transplantation (LT) is still controversial. The aim of this study was to review the current evidence investigating the effect of donor BMI on outcomes in patients undergoing LT. A systematic review was performed to evaluate relevant outcomes such as the availability of data on donor BMI as well as graft and patient survival after LT. Screening of 901 articles resulted in 11 observational studies for data extraction. In adult deceased donor after brain death and living donor LT, donor BMI was not associatedwith graft and patient survival. However, high donor BMIwas associated with a higher chance of macrosteatosis besides a significantly higher incidence of declined livers. In pediatric LT, severe obesity in adult donors with BMI >= 35 was associated with graft loss and mortality, whereas obesity in pediatric donors was not associated with graft loss and mortality. Accordingly, donor BMI is not associated with long-term outcomes in adult patients undergoing LT. However, further research should be conducted to identify the effect of donor BMI on outcomes in LT. (C) 2020 The Author(s). Published by Elsevier Inc.
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=eur_pure&SrcAuth=WosAPI&KeyUT=WOS:000579524600010&DestLinkType=FullRecord&DestApp=WOS
U2 - 10.1016/j.trre.2020.100571
DO - 10.1016/j.trre.2020.100571
M3 - Article
C2 - 33002669
SN - 0955-470X
VL - 34
JO - Transplantation Reviews
JF - Transplantation Reviews
IS - 4
M1 - 100571
ER -
