The Effect of Histopathological Growth Patterns of Colorectal Liver Metastases on the Survival Benefit of Adjuvant Hepatic Arterial Infusion Pump Chemotherapy

W. F. Filipe; Y. M. Meyer; F. E. Buisman; R. R.J.Coebergh van den Braak; B. Galjart; D. J. Höppener; W. R. Jarnagin; N. E. Kemeny; T. P. Kingham; P. M.H. Nierop; E. P. van der Stok; D. J. Grünhagen; P. B. Vermeulen; B. Groot Koerkamp; C. Verhoef; M. I. D’Angelica

doi:10.1245/s10434-023-14342-1

The Effect of Histopathological Growth Patterns of Colorectal Liver Metastases on the Survival Benefit of Adjuvant Hepatic Arterial Infusion Pump Chemotherapy

W. F. Filipe^*, Y. M. Meyer, F. E. Buisman, R. R.J.Coebergh van den Braak, B. Galjart, D. J. Höppener, W. R. Jarnagin, N. E. Kemeny, T. P. Kingham, P. M.H. Nierop, E. P. van der Stok, D. J. Grünhagen, P. B. Vermeulen, B. Groot Koerkamp, C. Verhoef^*, M. I. D’Angelica

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Background:

Histopathological growth patterns (HGPs) are a prognostic biomarker in colorectal liver metastases (CRLM). Desmoplastic HGP (dHGP) is associated with liver-only recurrence and superior overall survival (OS), while non-dHGP is associated with multi-organ recurrence and inferior OS. This study investigated the predictive value of HGPs for adjuvant hepatic arterial infusion pump (HAIP) chemotherapy in CRLM.

Methods:

Patients undergoing resection of CRLM and perioperative systemic chemotherapy in two centers were included. Survival outcomes and the predictive value of HAIP versus no HAIP per HGP group were evaluated through Kaplan–Meier and Cox regression methods, respectively.

Results:

We included 1233 patients. In the dHGP group (n = 291, 24%), HAIP chemotherapy was administered in 75 patients (26%). In the non-dHGP group (n = 942, 76%), HAIP chemotherapy was administered in 247 patients (26%). dHGP was associated with improved overall survival (OS, HR 0.49, 95% CI 0.32–0.73, p < 0.001). HAIP chemotherapy was associated with improved OS (HR 0.61, 95% CI 0.45–0.82, p < 0.001). No interaction could be demonstrated between HGP and HAIP on OS (HR 1.29, 95% CI 0.72–2.32, p = 0.40).

Conclusions:

There is no evidence that HGPs of CRLM modify the survival benefit of adjuvant HAIP chemotherapy in patients with resected CRLM.

Original language	English
Pages (from-to)	7996-8005
Number of pages	10
Journal	Annals of Surgical Oncology
Volume	30
Issue number	13
DOIs	https://doi.org/10.1245/s10434-023-14342-1
Publication status	Published - 2 Oct 2023

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Publisher Copyright:
© 2023, The Author(s).

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Filipe, W. F., Meyer, Y. M., Buisman, F. E., van den Braak, R. R. J. C., Galjart, B., Höppener, D. J., Jarnagin, W. R., Kemeny, N. E., Kingham, T. P., Nierop, P. M. H., van der Stok, E. P., Grünhagen, D. J., Vermeulen, P. B., Groot Koerkamp, B., Verhoef, C., & D’Angelica, M. I. (2023). The Effect of Histopathological Growth Patterns of Colorectal Liver Metastases on the Survival Benefit of Adjuvant Hepatic Arterial Infusion Pump Chemotherapy. Annals of Surgical Oncology, 30(13), 7996-8005. https://doi.org/10.1245/s10434-023-14342-1

@article{718ce7f73e2943c4b643cab2828f8717,

title = "The Effect of Histopathological Growth Patterns of Colorectal Liver Metastases on the Survival Benefit of Adjuvant Hepatic Arterial Infusion Pump Chemotherapy",

abstract = "Background: Histopathological growth patterns (HGPs) are a prognostic biomarker in colorectal liver metastases (CRLM). Desmoplastic HGP (dHGP) is associated with liver-only recurrence and superior overall survival (OS), while non-dHGP is associated with multi-organ recurrence and inferior OS. This study investigated the predictive value of HGPs for adjuvant hepatic arterial infusion pump (HAIP) chemotherapy in CRLM. Methods: Patients undergoing resection of CRLM and perioperative systemic chemotherapy in two centers were included. Survival outcomes and the predictive value of HAIP versus no HAIP per HGP group were evaluated through Kaplan–Meier and Cox regression methods, respectively. Results:We included 1233 patients. In the dHGP group (n = 291, 24%), HAIP chemotherapy was administered in 75 patients (26%). In the non-dHGP group (n = 942, 76%), HAIP chemotherapy was administered in 247 patients (26%). dHGP was associated with improved overall survival (OS, HR 0.49, 95% CI 0.32–0.73, p < 0.001). HAIP chemotherapy was associated with improved OS (HR 0.61, 95% CI 0.45–0.82, p < 0.001). No interaction could be demonstrated between HGP and HAIP on OS (HR 1.29, 95% CI 0.72–2.32, p = 0.40).Conclusions: There is no evidence that HGPs of CRLM modify the survival benefit of adjuvant HAIP chemotherapy in patients with resected CRLM.",

author = "Filipe, {W. F.} and Meyer, {Y. M.} and Buisman, {F. E.} and {van den Braak}, {R. R.J.Coebergh} and B. Galjart and H{\"o}ppener, {D. J.} and Jarnagin, {W. R.} and Kemeny, {N. E.} and Kingham, {T. P.} and Nierop, {P. M.H.} and {van der Stok}, {E. P.} and Gr{\"u}nhagen, {D. J.} and Vermeulen, {P. B.} and {Groot Koerkamp}, B. and C. Verhoef and D{\textquoteright}Angelica, {M. I.}",

note = "Publisher Copyright: {\textcopyright} 2023, The Author(s).",

year = "2023",

month = oct,

day = "2",

doi = "10.1245/s10434-023-14342-1",

language = "English",

volume = "30",

pages = "7996--8005",

journal = "Annals of Surgical Oncology",

issn = "1068-9265",

publisher = "Springer Science+Business Media",

number = "13",

}

Filipe, WF, Meyer, YM, Buisman, FE , van den Braak, RRJC , Galjart, B , Höppener, DJ, Jarnagin, WR, Kemeny, NE, Kingham, TP, Nierop, PMH, van der Stok, EP, Grünhagen, DJ, Vermeulen, PB, Groot Koerkamp, B , Verhoef, C & D’Angelica, MI 2023, 'The Effect of Histopathological Growth Patterns of Colorectal Liver Metastases on the Survival Benefit of Adjuvant Hepatic Arterial Infusion Pump Chemotherapy', Annals of Surgical Oncology, vol. 30, no. 13, pp. 7996-8005. https://doi.org/10.1245/s10434-023-14342-1

TY - JOUR

T1 - The Effect of Histopathological Growth Patterns of Colorectal Liver Metastases on the Survival Benefit of Adjuvant Hepatic Arterial Infusion Pump Chemotherapy

AU - Filipe, W. F.

AU - Meyer, Y. M.

AU - Buisman, F. E.

AU - van den Braak, R. R.J.Coebergh

AU - Galjart, B.

AU - Höppener, D. J.

AU - Jarnagin, W. R.

AU - Kemeny, N. E.

AU - Kingham, T. P.

AU - Nierop, P. M.H.

AU - van der Stok, E. P.

AU - Grünhagen, D. J.

AU - Vermeulen, P. B.

AU - Groot Koerkamp, B.

AU - Verhoef, C.

AU - D’Angelica, M. I.

PY - 2023/10/2

Y1 - 2023/10/2

N2 - Background: Histopathological growth patterns (HGPs) are a prognostic biomarker in colorectal liver metastases (CRLM). Desmoplastic HGP (dHGP) is associated with liver-only recurrence and superior overall survival (OS), while non-dHGP is associated with multi-organ recurrence and inferior OS. This study investigated the predictive value of HGPs for adjuvant hepatic arterial infusion pump (HAIP) chemotherapy in CRLM. Methods: Patients undergoing resection of CRLM and perioperative systemic chemotherapy in two centers were included. Survival outcomes and the predictive value of HAIP versus no HAIP per HGP group were evaluated through Kaplan–Meier and Cox regression methods, respectively. Results:We included 1233 patients. In the dHGP group (n = 291, 24%), HAIP chemotherapy was administered in 75 patients (26%). In the non-dHGP group (n = 942, 76%), HAIP chemotherapy was administered in 247 patients (26%). dHGP was associated with improved overall survival (OS, HR 0.49, 95% CI 0.32–0.73, p < 0.001). HAIP chemotherapy was associated with improved OS (HR 0.61, 95% CI 0.45–0.82, p < 0.001). No interaction could be demonstrated between HGP and HAIP on OS (HR 1.29, 95% CI 0.72–2.32, p = 0.40).Conclusions: There is no evidence that HGPs of CRLM modify the survival benefit of adjuvant HAIP chemotherapy in patients with resected CRLM.

AB - Background: Histopathological growth patterns (HGPs) are a prognostic biomarker in colorectal liver metastases (CRLM). Desmoplastic HGP (dHGP) is associated with liver-only recurrence and superior overall survival (OS), while non-dHGP is associated with multi-organ recurrence and inferior OS. This study investigated the predictive value of HGPs for adjuvant hepatic arterial infusion pump (HAIP) chemotherapy in CRLM. Methods: Patients undergoing resection of CRLM and perioperative systemic chemotherapy in two centers were included. Survival outcomes and the predictive value of HAIP versus no HAIP per HGP group were evaluated through Kaplan–Meier and Cox regression methods, respectively. Results:We included 1233 patients. In the dHGP group (n = 291, 24%), HAIP chemotherapy was administered in 75 patients (26%). In the non-dHGP group (n = 942, 76%), HAIP chemotherapy was administered in 247 patients (26%). dHGP was associated with improved overall survival (OS, HR 0.49, 95% CI 0.32–0.73, p < 0.001). HAIP chemotherapy was associated with improved OS (HR 0.61, 95% CI 0.45–0.82, p < 0.001). No interaction could be demonstrated between HGP and HAIP on OS (HR 1.29, 95% CI 0.72–2.32, p = 0.40).Conclusions: There is no evidence that HGPs of CRLM modify the survival benefit of adjuvant HAIP chemotherapy in patients with resected CRLM.

UR - http://www.scopus.com/inward/record.url?scp=85173968244&partnerID=8YFLogxK

U2 - 10.1245/s10434-023-14342-1

DO - 10.1245/s10434-023-14342-1

M3 - Article

C2 - 37782413

AN - SCOPUS:85173968244

SN - 1068-9265

VL - 30

SP - 7996

EP - 8005

JO - Annals of Surgical Oncology

JF - Annals of Surgical Oncology

IS - 13

ER -

The Effect of Histopathological Growth Patterns of Colorectal Liver Metastases on the Survival Benefit of Adjuvant Hepatic Arterial Infusion Pump Chemotherapy

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