The Effect of Histopathological Growth Patterns of Colorectal Liver Metastases on the Survival Benefit of Adjuvant Hepatic Arterial Infusion Pump Chemotherapy

W. F. Filipe*, Y. M. Meyer, F. E. Buisman, R. R.J.Coebergh van den Braak, B. Galjart, D. J. Höppener, W. R. Jarnagin, N. E. Kemeny, T. P. Kingham, P. M.H. Nierop, E. P. van der Stok, D. J. Grünhagen, P. B. Vermeulen, B. Groot Koerkamp, C. Verhoef*, M. I. D’Angelica

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Background: 

Histopathological growth patterns (HGPs) are a prognostic biomarker in colorectal liver metastases (CRLM). Desmoplastic HGP (dHGP) is associated with liver-only recurrence and superior overall survival (OS), while non-dHGP is associated with multi-organ recurrence and inferior OS. This study investigated the predictive value of HGPs for adjuvant hepatic arterial infusion pump (HAIP) chemotherapy in CRLM. 

Methods: 

Patients undergoing resection of CRLM and perioperative systemic chemotherapy in two centers were included. Survival outcomes and the predictive value of HAIP versus no HAIP per HGP group were evaluated through Kaplan–Meier and Cox regression methods, respectively. 

Results:

We included 1233 patients. In the dHGP group (n = 291, 24%), HAIP chemotherapy was administered in 75 patients (26%). In the non-dHGP group (n = 942, 76%), HAIP chemotherapy was administered in 247 patients (26%). dHGP was associated with improved overall survival (OS, HR 0.49, 95% CI 0.32–0.73, p < 0.001). HAIP chemotherapy was associated with improved OS (HR 0.61, 95% CI 0.45–0.82, p < 0.001). No interaction could be demonstrated between HGP and HAIP on OS (HR 1.29, 95% CI 0.72–2.32, p = 0.40).

Conclusions: 

There is no evidence that HGPs of CRLM modify the survival benefit of adjuvant HAIP chemotherapy in patients with resected CRLM.

Original languageEnglish
Pages (from-to)7996-8005
Number of pages10
JournalAnnals of Surgical Oncology
Volume30
Issue number13
DOIs
Publication statusPublished - 2 Oct 2023

Bibliographical note

Publisher Copyright:
© 2023, The Author(s).

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