The effect of hormone therapy on breast density following risk-reducing salpingo-oophorectomy in women with an increased risk for breast and ovarian cancer

Mark van Barele; Chistien C.M. Buis; Monique M.A. Brood-van Zanten; H. Lena C. van Doorn; Katja N. Gaarenstroom; Bernadette A.M. Heemskerk-Gerritsen; Maartje J. Hooning; Joanne de Hullu; Marian J. Mourits; Curt W. Burger

doi:10.1097/GME.0000000000001844

The effect of hormone therapy on breast density following risk-reducing salpingo-oophorectomy in women with an increased risk for breast and ovarian cancer

Mark van Barele^*, Chistien C.M. Buis, Monique M.A. Brood-van Zanten, H. Lena C. van Doorn, Katja N. Gaarenstroom, Bernadette A.M. Heemskerk-Gerritsen, Maartje J. Hooning, Joanne de Hullu, Marian J. Mourits, Curt W. Burger

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

OBJECTIVE: To compare the effect of tibolone to conjugated estrogens with medroxyprogesterone-acetate (CEE + MPA) on breast density, as a predictor for breast cancer risk, in women with a high risk of breast and ovarian cancer.

METHODS: Women aged 30-50 (N = 114) who had undergone risk-reducing salpingo-oophorectomy (RRSO) were randomized to tibolone or CEE + MPA.

RESULTS: Breast density decreased 46% after RRSO in untreated women, 39% after treatment with tibolone, and 17% after treatment with CEE + MPA; the decrease in breast density after CEE + MPA was significantly different compared with that of untreated women (P = 0.017).

CONCLUSIONS: A decline in breast density is seen after premenopausal RRSO despite the use of both CEE + MPA or tibolone, although lower breast density is seen after tibolone use.

Original language	English
Pages (from-to)	1307-1312
Number of pages	6
Journal	Menopause (New York, N.Y.)
Volume	28
Issue number	11
DOIs	https://doi.org/10.1097/GME.0000000000001844
Publication status	Published - Nov 2021

Bibliographical note

Funding/support: An unconditional grant from Organon, Oss, The
Netherlands

Publisher Copyright:
Copyright © 2021 by The North American Menopause Society.

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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van Barele, M., Buis, C. C. M., Brood-van Zanten, M. M. A., van Doorn, H. L. C., Gaarenstroom, K. N., Heemskerk-Gerritsen, B. A. M., Hooning, M. J., de Hullu, J., Mourits, M. J., & Burger, C. W. (2021). The effect of hormone therapy on breast density following risk-reducing salpingo-oophorectomy in women with an increased risk for breast and ovarian cancer. Menopause (New York, N.Y.), 28(11), 1307-1312. https://doi.org/10.1097/GME.0000000000001844

@article{32f70f49717d4b70bf6546ee6280df71,

title = "The effect of hormone therapy on breast density following risk-reducing salpingo-oophorectomy in women with an increased risk for breast and ovarian cancer",

abstract = "OBJECTIVE: To compare the effect of tibolone to conjugated estrogens with medroxyprogesterone-acetate (CEE + MPA) on breast density, as a predictor for breast cancer risk, in women with a high risk of breast and ovarian cancer. METHODS: Women aged 30-50 (N = 114) who had undergone risk-reducing salpingo-oophorectomy (RRSO) were randomized to tibolone or CEE + MPA. RESULTS: Breast density decreased 46% after RRSO in untreated women, 39% after treatment with tibolone, and 17% after treatment with CEE + MPA; the decrease in breast density after CEE + MPA was significantly different compared with that of untreated women (P = 0.017). CONCLUSIONS: A decline in breast density is seen after premenopausal RRSO despite the use of both CEE + MPA or tibolone, although lower breast density is seen after tibolone use.",

author = "{van Barele}, Mark and Buis, {Chistien C.M.} and {Brood-van Zanten}, {Monique M.A.} and {van Doorn}, {H. Lena C.} and Gaarenstroom, {Katja N.} and Heemskerk-Gerritsen, {Bernadette A.M.} and Hooning, {Maartje J.} and {de Hullu}, Joanne and Mourits, {Marian J.} and Burger, {Curt W.}",

note = "Funding/support: An unconditional grant from Organon, Oss, The Netherlands Publisher Copyright: Copyright {\textcopyright} 2021 by The North American Menopause Society.",

year = "2021",

month = nov,

doi = "10.1097/GME.0000000000001844",

language = "English",

volume = "28",

pages = "1307--1312",

journal = "Menopause",

issn = "1072-3714",

publisher = "Lippincott Williams & Wilkins",

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}

van Barele, M, Buis, CCM, Brood-van Zanten, MMA, van Doorn, HLC, Gaarenstroom, KN, Heemskerk-Gerritsen, BAM , Hooning, MJ, de Hullu, J, Mourits, MJ & Burger, CW 2021, 'The effect of hormone therapy on breast density following risk-reducing salpingo-oophorectomy in women with an increased risk for breast and ovarian cancer', Menopause (New York, N.Y.), vol. 28, no. 11, pp. 1307-1312. https://doi.org/10.1097/GME.0000000000001844

The effect of hormone therapy on breast density following risk-reducing salpingo-oophorectomy in women with an increased risk for breast and ovarian cancer. / van Barele, Mark; Buis, Chistien C.M.; Brood-van Zanten, Monique M.A. et al.
In: Menopause (New York, N.Y.), Vol. 28, No. 11, 11.2021, p. 1307-1312.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - The effect of hormone therapy on breast density following risk-reducing salpingo-oophorectomy in women with an increased risk for breast and ovarian cancer

AU - van Barele, Mark

AU - Buis, Chistien C.M.

AU - Brood-van Zanten, Monique M.A.

AU - van Doorn, H. Lena C.

AU - Gaarenstroom, Katja N.

AU - Heemskerk-Gerritsen, Bernadette A.M.

AU - Hooning, Maartje J.

AU - de Hullu, Joanne

AU - Mourits, Marian J.

AU - Burger, Curt W.

PY - 2021/11

Y1 - 2021/11

N2 - OBJECTIVE: To compare the effect of tibolone to conjugated estrogens with medroxyprogesterone-acetate (CEE + MPA) on breast density, as a predictor for breast cancer risk, in women with a high risk of breast and ovarian cancer. METHODS: Women aged 30-50 (N = 114) who had undergone risk-reducing salpingo-oophorectomy (RRSO) were randomized to tibolone or CEE + MPA. RESULTS: Breast density decreased 46% after RRSO in untreated women, 39% after treatment with tibolone, and 17% after treatment with CEE + MPA; the decrease in breast density after CEE + MPA was significantly different compared with that of untreated women (P = 0.017). CONCLUSIONS: A decline in breast density is seen after premenopausal RRSO despite the use of both CEE + MPA or tibolone, although lower breast density is seen after tibolone use.

AB - OBJECTIVE: To compare the effect of tibolone to conjugated estrogens with medroxyprogesterone-acetate (CEE + MPA) on breast density, as a predictor for breast cancer risk, in women with a high risk of breast and ovarian cancer. METHODS: Women aged 30-50 (N = 114) who had undergone risk-reducing salpingo-oophorectomy (RRSO) were randomized to tibolone or CEE + MPA. RESULTS: Breast density decreased 46% after RRSO in untreated women, 39% after treatment with tibolone, and 17% after treatment with CEE + MPA; the decrease in breast density after CEE + MPA was significantly different compared with that of untreated women (P = 0.017). CONCLUSIONS: A decline in breast density is seen after premenopausal RRSO despite the use of both CEE + MPA or tibolone, although lower breast density is seen after tibolone use.

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DO - 10.1097/GME.0000000000001844

M3 - Article

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AN - SCOPUS:85121477163

SN - 1072-3714

VL - 28

SP - 1307

EP - 1312

JO - Menopause

JF - Menopause

IS - 11

ER -

The effect of hormone therapy on breast density following risk-reducing salpingo-oophorectomy in women with an increased risk for breast and ovarian cancer

Abstract

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