The effect of hormone therapy on breast density following riskreducing salpingo-oophorectomy in women with an increased risk for breast and ovarian cancer

M (Mark) van Barele, CCM (Christien) Buis, MMA Brood-van Zanten, Lena van Doorn, KN Gaarenstroom, Bernadette A.M. Heemskerk-Gerritsen, Maartje Hooning, Joanne A. De Hullu, MJ Mourits, CW (Curt) Burger

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Objective:
To compare the effect of tibolone to conjugated estrogens with medroxyprogesterone-acetate (CEE + MPA) on breast density, as a predictor for breast cancer risk, in women with a high risk of breast and ovarian cancer.

Methods:
Women aged 30-50 (N = 114) who had undergone risk-reducing salpingo-oophorectomy (RRSO) were randomized to tibolone or CEE + MPA.

Results:
Breast density decreased 46% after RRSO in untreated women, 39% after treatment with tibolone, and 17% after treatment with CEE + MPA; the decrease in breast density after CEE + MPA was significantly different compared with that of untreated women (P = 0.017).

Conclusions:
A decline in breast density is seen after premenopausal RRSO despite the use of both CEE + MPA or tibolone, although lower breast density is seen after tibolone use.
Original languageEnglish
Pages (from-to)1307-1312
JournalMenopause
Volume28
Issue number11
DOIs
Publication statusPublished - 1 Aug 2021

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