Abstract
The response to vitamin K antagonists (VKAs) is determined by many different factors like age, weight, height, vitamin K intake and genetic polymorphisms [1]. The proton pump inhibitors (PPIs) omeprazole and esomeprazole may enhance the effect of VKAs by inhibition of the hepatic metabolism of coumarins [2]. Some isolated cases have been reported of clinically significant elevated INRs in patients concomitantly using omeprazole and phenprocoumon, a VKA frequently used in Europe [3].Practical experience suggests an interaction between omeprazole or esomeprazole and phenprocoumon, but scientific evidence is still lacking.
Original language | English |
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Pages (from-to) | 1068-1069 |
Number of pages | 2 |
Journal | British Journal of Clinical Pharmacology |
Volume | 74 |
Issue number | 6 |
DOIs | |
Publication status | Published - 2012 |
Research programs
- EMC NIHES-05-63-02 Quality