The effect of omeprazole and esomeprazole on the maintenance dose of phenprocoumon

TI Verhoef, MJL Zuurhout, RMF van Schie, Ken Redekop, FJM van der Meer, S le Cessie, T Schalekamp, A de Boer, AH Maitland-van der Zee

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Scopus)

Abstract

The response to vitamin K antagonists (VKAs) is determined by many different factors like age, weight, height, vitamin K intake and genetic polymorphisms [1]. The proton pump inhibitors (PPIs) omeprazole and esomeprazole may enhance the effect of VKAs by inhibition of the hepatic metabolism of coumarins [2]. Some isolated cases have been reported of clinically significant elevated INRs in patients concomitantly using omeprazole and phenprocoumon, a VKA frequently used in Europe [3].Practical experience suggests an interaction between omeprazole or esomeprazole and phenprocoumon, but scientific evidence is still lacking.
Original languageEnglish
Pages (from-to)1068-1069
Number of pages2
JournalBritish Journal of Clinical Pharmacology
Volume74
Issue number6
DOIs
Publication statusPublished - 2012

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