The effect of smoking on early chorionic villous vascularisation

Robbert Oppenraaij, Anton Koning, MJB van den Hoff, Peter van der Spek, Eric Steegers, Exalto

Research output: Contribution to journalArticleAcademicpeer-review

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The aim aim of the study was to investigate whether first trimester chorionic villous vascularisation is different in women who smoked cigarettes before and during pregnancy in comparison with women who did not smoke. Placentas of smoking (>10 cigarettes/day, n = 13) and non-smoking women (n = 13), scheduled for a legal termination of a viable first trimester pregnancy for social indications, were retrieved. Placental tissues of 3-5 mm(3) were whole mount CD31 immunofluorescence stained. Images of the CD31 immunofluorescence and contour of the villi were captured using an Optical Projection Tomography scanner. An immersive BARCO virtual reality system was used to create an enlarged interactive 3-dimensional h In conclusion, chorionic villous vascularisation is already altered in first trimester of pregnancy in women who smoked cigarettes before and during pregnancy. (C) 2012 Elsevier Ltd. All rights reserved.
Original languageUndefined/Unknown
Pages (from-to)645-651
Number of pages7
Issue number8
Publication statusPublished - 2012

Research programs

  • EMC MGC-02-02-01
  • EMC MGC-02-52-01-A

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