The Effects of Intra-Aortic Balloon Pump Support on Macrocirculation and Tissue Microcirculation in Patients with Cardiogenic Shock

Objectives: It was the aim of this study to evaluate the effects of intra-aortic balloon pump (IABP) counterpulsation on sublingual microcirculation as a model for tissue perfusion. Methods: In 13 patients with cardiogenic shock treated with IABP, the IABP assist ratio was reduced from 1: 1 to 1: 8 for 15 min. Using sidestream dark field imaging, 117 movie files of the sublingual microcirculation were obtained and quantified at different IABP assist ratios at 3 time points: 1: 1 (T0), 1: 8 (T1) and 1: 1 (T2), respectively. Data are presented as the median and interquartile range. Results: The median age of the patients was 59 years (range 56-73), and 62% were males. Discontinuation of IABP decreased the mean arterial pressure [75 mm Hg (71-84) at T0 vs. 69 mm Hg (64 -79) at T1; p < 0.001], cardiac index [2.9 l/min/m(2) (1.6-3.3) at T0 vs. 2.4 l/min/m(2) (1.5-2.8) at T1; p = 0.005] and cardiac power index [0.46 W/m(2) (0.29 -0.59) at T0 vs. 0.36 W/m(2) (0.24 -0.50) at T1; p = 0.006]. However, these modest changes in macrohemodynamics did not significantly influence sublingual perfused capillary density and capillary red blood cell velocity (p = 0.28 and 0.73, respectively). Conclusion: A temporary, modest decrease in microcirculatory driving force, induced by lowering the IABP assist ratio, does not impair sublingual microcirculatory perfusion as measured by a novel 2-dimensional imaging technique. Copyright (C) 2009 S. Karger AG, Basel