The etransafe project on translational safety assessment through integrative knowledge management: Achievements and perspectives

François Pognan; Thomas Steger‐hartmann; Carlos Díaz; Niklas Blomberg; Frank Bringezu; Katharine Briggs; Giulia Callegaro; Salvador Capella‐gutierrez; Emilio Centeno; Javier Corvi; Philip Drew; William C. Drewe; José M. Fernández; Laura I. Furlong; Emre Guney; Jan A. Kors; Miguel Angel Mayer; Manuel Pastor; Janet Piñero; Juan Manuel Ramírez‐anguita; Francesco Ronzano; Philip Rowell; Josep Saüch‐pitarch; Alfonso Valencia; Bob van de Water; Johan van der Lei; Erik van Mulligen; Ferran Sanz

doi:10.3390/ph14030237

The etransafe project on translational safety assessment through integrative knowledge management: Achievements and perspectives

François Pognan, Thomas Steger‐hartmann, Carlos Díaz, Niklas Blomberg, Frank Bringezu, Katharine Briggs, Giulia Callegaro, Salvador Capella‐gutierrez, Emilio Centeno, Javier Corvi, Philip Drew, William C. Drewe, José M. Fernández, Laura I. Furlong, Emre Guney, Jan A. Kors, Miguel Angel Mayer, Manuel Pastor, Janet Piñero, Juan Manuel Ramírez‐anguitaFrancesco Ronzano, Philip Rowell, Josep Saüch‐pitarch, Alfonso Valencia, Bob van de Water, Johan van der Lei, Erik van Mulligen, Ferran Sanz^*

^*Corresponding author for this work

Medical Informatics

Research output: Contribution to journal › Article › Academic › peer-review

22 Citations (Scopus)

17 Downloads (Pure)

Abstract

eTRANSAFE is a research project funded within the Innovative Medicines Initiative (IMI), which aims at developing integrated databases and computational tools (the eTRANSAFE ToxHub) that support the translational safety assessment of new drugs by using legacy data provided by the pharmaceutical companies that participate in the project. The project objectives include the development of databases containing preclinical and clinical data, computational systems for translational analysis including tools for data query, analysis and visualization, as well as computational models to explain and predict drug safety events.

Original language	English
Article number	237
Journal	Pharmaceuticals
Volume	14
Issue number	3
DOIs	https://doi.org/10.3390/ph14030237
Publication status	Published - Mar 2021

Bibliographical note

Funding Information:
Funding: This research received funding from the Innovative Medicines Initiative 2 Joint Undertak‐ ing under grant agreements eTRANSAFE (777365). This Joint Undertaking receives support from the European Union’s Horizon 2020 research and innovation programme and EFPIA companies in kind contribution.

Funding Information:
Acknowledgments: The Research Programme on Biomedical Informatics (GRIB) of IMIM and DCEXS‐UPF is a member of the Spanish National Bioinformatics Institute (INB), PRB2‐ISCIII and is supported by grant PT13/0001/0023, of the PE I + D + i 2013–2016, funded by ISCIII and FEDER. The GRIB also receive support from Agència de Gestió D’ajuts Universitaris i de Recerca Generalitat de Catalunya (AGAUR, ref.: 2017SGR01020). The DCEXS is a “Unidad de Excelencia María de Ma‐ eztu”, funded by the MINECO (ref: MDM‐2014‐0370).

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Access to Document

10.3390/ph14030237Licence: CC BY

The eTRANSAFE Project on Translational Safety Assessment through Integrative Knowledge ManagementFinal published version, 4.7 MBLicence: CC BY

Cite this

Pognan, F., Steger‐hartmann, T., Díaz, C., Blomberg, N., Bringezu, F., Briggs, K., Callegaro, G., Capella‐gutierrez, S., Centeno, E., Corvi, J., Drew, P., Drewe, W. C., Fernández, J. M., Furlong, L. I., Guney, E., Kors, J. A., Mayer, M. A., Pastor, M., Piñero, J., ... Sanz, F. (2021). The etransafe project on translational safety assessment through integrative knowledge management: Achievements and perspectives. Pharmaceuticals, 14(3), Article 237. https://doi.org/10.3390/ph14030237

@article{69a2ea5a81d14779b67d5a893f34dd2b,

title = "The etransafe project on translational safety assessment through integrative knowledge management: Achievements and perspectives",

abstract = "eTRANSAFE is a research project funded within the Innovative Medicines Initiative (IMI), which aims at developing integrated databases and computational tools (the eTRANSAFE ToxHub) that support the translational safety assessment of new drugs by using legacy data provided by the pharmaceutical companies that participate in the project. The project objectives include the development of databases containing preclinical and clinical data, computational systems for translational analysis including tools for data query, analysis and visualization, as well as computational models to explain and predict drug safety events.",

author = "Fran{\c c}ois Pognan and Thomas Steger‐hartmann and Carlos D{\'i}az and Niklas Blomberg and Frank Bringezu and Katharine Briggs and Giulia Callegaro and Salvador Capella‐gutierrez and Emilio Centeno and Javier Corvi and Philip Drew and Drewe, {William C.} and Fern{\'a}ndez, {Jos{\'e} M.} and Furlong, {Laura I.} and Emre Guney and Kors, {Jan A.} and Mayer, {Miguel Angel} and Manuel Pastor and Janet Pi{\~n}ero and Ram{\'i}rez‐anguita, {Juan Manuel} and Francesco Ronzano and Philip Rowell and Josep Sa{\"u}ch‐pitarch and Alfonso Valencia and {van de Water}, Bob and {van der Lei}, Johan and {van Mulligen}, Erik and Ferran Sanz",

note = "Funding Information: Funding: This research received funding from the Innovative Medicines Initiative 2 Joint Undertak‐ ing under grant agreements eTRANSAFE (777365). This Joint Undertaking receives support from the European Union{\textquoteright}s Horizon 2020 research and innovation programme and EFPIA companies in kind contribution. Funding Information: Acknowledgments: The Research Programme on Biomedical Informatics (GRIB) of IMIM and DCEXS‐UPF is a member of the Spanish National Bioinformatics Institute (INB), PRB2‐ISCIII and is supported by grant PT13/0001/0023, of the PE I + D + i 2013–2016, funded by ISCIII and FEDER. The GRIB also receive support from Ag{\`e}ncia de Gesti{\'o} D{\textquoteright}ajuts Universitaris i de Recerca Generalitat de Catalunya (AGAUR, ref.: 2017SGR01020). The DCEXS is a “Unidad de Excelencia Mar{\'i}a de Ma‐ eztu”, funded by the MINECO (ref: MDM‐2014‐0370). Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

month = mar,

doi = "10.3390/ph14030237",

language = "English",

volume = "14",

journal = "Pharmaceuticals",

issn = "1424-8247",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "3",

}

Pognan, F, Steger‐hartmann, T, Díaz, C, Blomberg, N, Bringezu, F, Briggs, K, Callegaro, G, Capella‐gutierrez, S, Centeno, E, Corvi, J, Drew, P, Drewe, WC, Fernández, JM, Furlong, LI, Guney, E, Kors, JA, Mayer, MA, Pastor, M, Piñero, J, Ramírez‐anguita, JM, Ronzano, F, Rowell, P, Saüch‐pitarch, J, Valencia, A, van de Water, B, van der Lei, J , van Mulligen, E & Sanz, F 2021, 'The etransafe project on translational safety assessment through integrative knowledge management: Achievements and perspectives', Pharmaceuticals, vol. 14, no. 3, 237. https://doi.org/10.3390/ph14030237

TY - JOUR

T1 - The etransafe project on translational safety assessment through integrative knowledge management

T2 - Achievements and perspectives

AU - Pognan, François

AU - Steger‐hartmann, Thomas

AU - Díaz, Carlos

AU - Blomberg, Niklas

AU - Bringezu, Frank

AU - Briggs, Katharine

AU - Callegaro, Giulia

AU - Capella‐gutierrez, Salvador

AU - Centeno, Emilio

AU - Corvi, Javier

AU - Drew, Philip

AU - Drewe, William C.

AU - Fernández, José M.

AU - Furlong, Laura I.

AU - Guney, Emre

AU - Kors, Jan A.

AU - Mayer, Miguel Angel

AU - Pastor, Manuel

AU - Piñero, Janet

AU - Ramírez‐anguita, Juan Manuel

AU - Ronzano, Francesco

AU - Rowell, Philip

AU - Saüch‐pitarch, Josep

AU - Valencia, Alfonso

AU - van de Water, Bob

AU - van der Lei, Johan

AU - van Mulligen, Erik

AU - Sanz, Ferran

N1 - Funding Information: Funding: This research received funding from the Innovative Medicines Initiative 2 Joint Undertak‐ ing under grant agreements eTRANSAFE (777365). This Joint Undertaking receives support from the European Union’s Horizon 2020 research and innovation programme and EFPIA companies in kind contribution. Funding Information: Acknowledgments: The Research Programme on Biomedical Informatics (GRIB) of IMIM and DCEXS‐UPF is a member of the Spanish National Bioinformatics Institute (INB), PRB2‐ISCIII and is supported by grant PT13/0001/0023, of the PE I + D + i 2013–2016, funded by ISCIII and FEDER. The GRIB also receive support from Agència de Gestió D’ajuts Universitaris i de Recerca Generalitat de Catalunya (AGAUR, ref.: 2017SGR01020). The DCEXS is a “Unidad de Excelencia María de Ma‐ eztu”, funded by the MINECO (ref: MDM‐2014‐0370). Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2021/3

Y1 - 2021/3

N2 - eTRANSAFE is a research project funded within the Innovative Medicines Initiative (IMI), which aims at developing integrated databases and computational tools (the eTRANSAFE ToxHub) that support the translational safety assessment of new drugs by using legacy data provided by the pharmaceutical companies that participate in the project. The project objectives include the development of databases containing preclinical and clinical data, computational systems for translational analysis including tools for data query, analysis and visualization, as well as computational models to explain and predict drug safety events.

AB - eTRANSAFE is a research project funded within the Innovative Medicines Initiative (IMI), which aims at developing integrated databases and computational tools (the eTRANSAFE ToxHub) that support the translational safety assessment of new drugs by using legacy data provided by the pharmaceutical companies that participate in the project. The project objectives include the development of databases containing preclinical and clinical data, computational systems for translational analysis including tools for data query, analysis and visualization, as well as computational models to explain and predict drug safety events.

UR - http://www.scopus.com/inward/record.url?scp=85103045533&partnerID=8YFLogxK

U2 - 10.3390/ph14030237

DO - 10.3390/ph14030237

M3 - Article

C2 - 33800393

AN - SCOPUS:85103045533

SN - 1424-8247

VL - 14

JO - Pharmaceuticals

JF - Pharmaceuticals

IS - 3

M1 - 237

ER -

The etransafe project on translational safety assessment through integrative knowledge management: Achievements and perspectives

Abstract

Bibliographical note

Access to Document

Other files and links

Fingerprint

Cite this