The Extracellular Matrix and Cardiac Pressure Overload: Focus on Novel Treatment Targets

Matthijs Snelders; Meltem Yildirim; A. H. Jan Danser; Ingrid van der Pluijm; Jeroen Essers

doi:10.3390/cells13201685

The Extracellular Matrix and Cardiac Pressure Overload: Focus on Novel Treatment Targets

Matthijs Snelders, Meltem Yildirim, A. H. Jan Danser, Ingrid van der Pluijm, Jeroen Essers^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › Academic › peer-review

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Abstract

Heart failure is a significant health issue in developed countries, often stemming from conditions like hypertension, which imposes a pressure overload on the heart. Despite various treatment strategies for heart failure, many lack long-term effectiveness. A critical aspect of cardiac disease is the remodeling of the heart, where compensatory changes in the extracellular matrix exacerbate disease progression. This review explores the processes and changes occurring in the pressure-overloaded heart with respect to the extracellular matrix. It further summarizes current treatment strategies, and then focuses on novel treatment targets for maladaptive cardiac remodeling, derived from transverse aortic constriction-induced pressure overload animal models.

Original language	English
Article number	1685
Journal	Cells
Volume	13
Issue number	20
DOIs	https://doi.org/10.3390/cells13201685
Publication status	Published - 12 Oct 2024

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title = "The Extracellular Matrix and Cardiac Pressure Overload: Focus on Novel Treatment Targets",

abstract = "Heart failure is a significant health issue in developed countries, often stemming from conditions like hypertension, which imposes a pressure overload on the heart. Despite various treatment strategies for heart failure, many lack long-term effectiveness. A critical aspect of cardiac disease is the remodeling of the heart, where compensatory changes in the extracellular matrix exacerbate disease progression. This review explores the processes and changes occurring in the pressure-overloaded heart with respect to the extracellular matrix. It further summarizes current treatment strategies, and then focuses on novel treatment targets for maladaptive cardiac remodeling, derived from transverse aortic constriction-induced pressure overload animal models.",

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AU - van der Pluijm, Ingrid

AU - Essers, Jeroen

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N2 - Heart failure is a significant health issue in developed countries, often stemming from conditions like hypertension, which imposes a pressure overload on the heart. Despite various treatment strategies for heart failure, many lack long-term effectiveness. A critical aspect of cardiac disease is the remodeling of the heart, where compensatory changes in the extracellular matrix exacerbate disease progression. This review explores the processes and changes occurring in the pressure-overloaded heart with respect to the extracellular matrix. It further summarizes current treatment strategies, and then focuses on novel treatment targets for maladaptive cardiac remodeling, derived from transverse aortic constriction-induced pressure overload animal models.

AB - Heart failure is a significant health issue in developed countries, often stemming from conditions like hypertension, which imposes a pressure overload on the heart. Despite various treatment strategies for heart failure, many lack long-term effectiveness. A critical aspect of cardiac disease is the remodeling of the heart, where compensatory changes in the extracellular matrix exacerbate disease progression. This review explores the processes and changes occurring in the pressure-overloaded heart with respect to the extracellular matrix. It further summarizes current treatment strategies, and then focuses on novel treatment targets for maladaptive cardiac remodeling, derived from transverse aortic constriction-induced pressure overload animal models.

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JO - Cells

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The Extracellular Matrix and Cardiac Pressure Overload: Focus on Novel Treatment Targets

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