The extracellular matrix as hallmark of cancer and metastasis: From biomechanics to therapeutic targets

Jelle J F Sleeboom, Gilles S van Tienderen, Katja Schenke-Layland, Luc J W van der Laan, Antoine A Khalil*, Monique M A Verstegen*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

6 Citations (Scopus)

Abstract

The extracellular matrix (ECM) is essential for cell support during homeostasis and plays a critical role in cancer. Although research often concentrates on the tumor's cellular aspect, attention is growing for the importance of the cancer-associated ECM. Biochemical and physical ECM signals affect tumor formation, invasion, metastasis, and therapy resistance. Examining the tumor microenvironment uncovers intricate ECM dysregulation and interactions with cancer and stromal cells. Anticancer therapies targeting ECM sensors and remodelers, including integrins and matrix metalloproteinases, and ECM-remodeling cells, have seen limited success. This review explores the ECM's role in cancer and discusses potential therapeutic strategies for cell-ECM interactions.

Original languageEnglish
Article number3840
Pages (from-to)eadg3840
JournalScience Translational Medicine
Volume16
Issue number728
DOIs
Publication statusPublished - 3 Jan 2024

Bibliographical note

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© 2024 The authors, some rights reserved; exclusive licensee american association for the advancement of Science. no claim to original U.S. Government works.

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