The extracellular matrix as hallmark of cancer and metastasis: From biomechanics to therapeutic targets

Jelle J F Sleeboom; Gilles S van Tienderen; Katja Schenke-Layland; Luc J W van der Laan; Antoine A Khalil; Monique M A Verstegen

doi:10.1126/scitranslmed.adg3840

The extracellular matrix as hallmark of cancer and metastasis: From biomechanics to therapeutic targets

Jelle J F Sleeboom
, Gilles S van Tienderen
, Katja Schenke-Layland
, Luc J W van der Laan
, Antoine A Khalil^*
, Monique M A Verstegen^*

^*Corresponding author for this work

Surgery

Erasmus University Medical Centre
Eberhard Karls University Hospital
University Medical Centre Utrecht

Research output: Contribution to journal › Review article › Academic › peer-review

331 Citations (Scopus)

823 Downloads (Pure)

Abstract

The extracellular matrix (ECM) is essential for cell support during homeostasis and plays a critical role in cancer. Although research often concentrates on the tumor's cellular aspect, attention is growing for the importance of the cancer-associated ECM. Biochemical and physical ECM signals affect tumor formation, invasion, metastasis, and therapy resistance. Examining the tumor microenvironment uncovers intricate ECM dysregulation and interactions with cancer and stromal cells. Anticancer therapies targeting ECM sensors and remodelers, including integrins and matrix metalloproteinases, and ECM-remodeling cells, have seen limited success. This review explores the ECM's role in cancer and discusses potential therapeutic strategies for cell-ECM interactions.

Original language	English
Article number	3840
Pages (from-to)	eadg3840
Journal	Science Translational Medicine
Volume	16
Issue number	728
DOIs	https://doi.org/10.1126/scitranslmed.adg3840
Publication status	Published - 3 Jan 2024

Bibliographical note

Publisher Copyright:
© 2024 The authors, some rights reserved; exclusive licensee american association for the advancement of Science. no claim to original U.S. Government works.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1126/scitranslmed.adg3840

The extracellular matrix as hallmark of cancer and metastasisFinal published version, 3.26 MBLicence: Article 25fa Dutch Copyright Act

Cite this

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title = "The extracellular matrix as hallmark of cancer and metastasis: From biomechanics to therapeutic targets",

abstract = "The extracellular matrix (ECM) is essential for cell support during homeostasis and plays a critical role in cancer. Although research often concentrates on the tumor's cellular aspect, attention is growing for the importance of the cancer-associated ECM. Biochemical and physical ECM signals affect tumor formation, invasion, metastasis, and therapy resistance. Examining the tumor microenvironment uncovers intricate ECM dysregulation and interactions with cancer and stromal cells. Anticancer therapies targeting ECM sensors and remodelers, including integrins and matrix metalloproteinases, and ECM-remodeling cells, have seen limited success. This review explores the ECM's role in cancer and discusses potential therapeutic strategies for cell-ECM interactions.",

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AU - Sleeboom, Jelle J F

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AU - van der Laan, Luc J W

AU - Khalil, Antoine A

AU - Verstegen, Monique M A

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AB - The extracellular matrix (ECM) is essential for cell support during homeostasis and plays a critical role in cancer. Although research often concentrates on the tumor's cellular aspect, attention is growing for the importance of the cancer-associated ECM. Biochemical and physical ECM signals affect tumor formation, invasion, metastasis, and therapy resistance. Examining the tumor microenvironment uncovers intricate ECM dysregulation and interactions with cancer and stromal cells. Anticancer therapies targeting ECM sensors and remodelers, including integrins and matrix metalloproteinases, and ECM-remodeling cells, have seen limited success. This review explores the ECM's role in cancer and discusses potential therapeutic strategies for cell-ECM interactions.

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The extracellular matrix as hallmark of cancer and metastasis: From biomechanics to therapeutic targets

Abstract

Bibliographical note

UN SDGs

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