The fat-mass and obesity-associated gene (FTO) predicts mortality in chronic kidney disease of various severity

B (Belinda) Spoto; F.U.S. Mattace Raso; E.J.G. Sijbrands; F Mallamaci; D Leonardis; F Aucella; A Testa; A Gesuete; MC Sanguedolce; G D'Arrigo; RM Parlongo; A Pisano; C (Claudia) Torino; G Enia; G Tripepi; M Postorino; C Zoccali

doi:10.1093/ndt/gfs550

The fat-mass and obesity-associated gene (FTO) predicts mortality in chronic kidney disease of various severity

B (Belinda) Spoto, F.U.S. Mattace Raso, E.J.G. Sijbrands, F Mallamaci, D Leonardis, F Aucella, A Testa, A Gesuete, MC Sanguedolce, G D'Arrigo, RM Parlongo, A Pisano, C (Claudia) Torino, G Enia, G Tripepi, M Postorino, C Zoccali

Internal Medicine

Research output: Contribution to journal › Article › Academic › peer-review

16 Citations (Scopus)

Abstract

Polymorphisms in the FTO (fat-mass and obesity-associated) gene have been associated with the body mass index, cancer, type 2 diabetes and hypertension. We investigated the relationship between 17 tag single-nucleotide polymorphisms (SNPs) and all-cause mortality in three cohorts of dialysis patients (CREED-1, North Apulian and CREED-2 cohorts; n 783) and in one cohort of stage 25 CKD patients (n 757). We first explored the association between the 17 tag SNPs and all-cause mortality in the CREED-1 cohort and found that patients with the A allele of the FTO rs708259 polymorphism had an elevated risk of mortality (hazard ratio, HR: 1.52, 95 confidence interval (CI) 1.112.08; P 0.008). Similarly, the A allele was associated with an increased risk of death also in the other two dialysis cohorts (North Apulian cohort, risk: 23; CREED-2 cohort, risk: 21). The elevated risk portended by this allele w The A allele of the FTO rs708259 polymorphism is an independent predictor of all-cause mortality in patients with CKD of various severity. These data support our hypothesis that the FTO gene may be a relevant genetic risk factor for mortality in this population.

Original language	Undefined/Unknown
Pages (from-to)	iv58-iv62
Journal	Nephrology Dialysis Transplantation
Volume	27
DOIs	https://doi.org/10.1093/ndt/gfs550
Publication status	Published - 2012

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10.1093/ndt/gfs550

http://hdl.handle.net/1765/66271

Cite this

Spoto, B., Mattace Raso, F. U. S., Sijbrands, E. J. G., Mallamaci, F., Leonardis, D., Aucella, F., Testa, A., Gesuete, A., Sanguedolce, MC., D'Arrigo, G., Parlongo, RM., Pisano, A., Torino, C., Enia, G., Tripepi, G., Postorino, M., & Zoccali, C. (2012). The fat-mass and obesity-associated gene (FTO) predicts mortality in chronic kidney disease of various severity. Nephrology Dialysis Transplantation, 27, iv58-iv62. https://doi.org/10.1093/ndt/gfs550

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title = "The fat-mass and obesity-associated gene (FTO) predicts mortality in chronic kidney disease of various severity",

abstract = "Polymorphisms in the FTO (fat-mass and obesity-associated) gene have been associated with the body mass index, cancer, type 2 diabetes and hypertension. We investigated the relationship between 17 tag single-nucleotide polymorphisms (SNPs) and all-cause mortality in three cohorts of dialysis patients (CREED-1, North Apulian and CREED-2 cohorts; n 783) and in one cohort of stage 25 CKD patients (n 757). We first explored the association between the 17 tag SNPs and all-cause mortality in the CREED-1 cohort and found that patients with the A allele of the FTO rs708259 polymorphism had an elevated risk of mortality (hazard ratio, HR: 1.52, 95 confidence interval (CI) 1.112.08; P 0.008). Similarly, the A allele was associated with an increased risk of death also in the other two dialysis cohorts (North Apulian cohort, risk: 23; CREED-2 cohort, risk: 21). The elevated risk portended by this allele w The A allele of the FTO rs708259 polymorphism is an independent predictor of all-cause mortality in patients with CKD of various severity. These data support our hypothesis that the FTO gene may be a relevant genetic risk factor for mortality in this population.",

author = "Spoto, {B (Belinda)} and {Mattace Raso}, F.U.S. and E.J.G. Sijbrands and F Mallamaci and D Leonardis and F Aucella and A Testa and A Gesuete and MC Sanguedolce and G D'Arrigo and RM Parlongo and A Pisano and Torino, {C (Claudia)} and G Enia and G Tripepi and M Postorino and C Zoccali",

year = "2012",

doi = "10.1093/ndt/gfs550",

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Spoto, B, Mattace Raso, FUS , Sijbrands, EJG, Mallamaci, F, Leonardis, D, Aucella, F, Testa, A, Gesuete, A, Sanguedolce, MC, D'Arrigo, G, Parlongo, RM, Pisano, A, Torino, C, Enia, G, Tripepi, G, Postorino, M & Zoccali, C 2012, 'The fat-mass and obesity-associated gene (FTO) predicts mortality in chronic kidney disease of various severity', Nephrology Dialysis Transplantation, vol. 27, pp. iv58-iv62. https://doi.org/10.1093/ndt/gfs550

TY - JOUR

T1 - The fat-mass and obesity-associated gene (FTO) predicts mortality in chronic kidney disease of various severity

AU - Spoto, B (Belinda)

AU - Mattace Raso, F.U.S.

AU - Sijbrands, E.J.G.

AU - Mallamaci, F

AU - Leonardis, D

AU - Aucella, F

AU - Testa, A

AU - Gesuete, A

AU - Sanguedolce, MC

AU - D'Arrigo, G

AU - Parlongo, RM

AU - Pisano, A

AU - Torino, C (Claudia)

AU - Enia, G

AU - Tripepi, G

AU - Postorino, M

AU - Zoccali, C

PY - 2012

Y1 - 2012

N2 - Polymorphisms in the FTO (fat-mass and obesity-associated) gene have been associated with the body mass index, cancer, type 2 diabetes and hypertension. We investigated the relationship between 17 tag single-nucleotide polymorphisms (SNPs) and all-cause mortality in three cohorts of dialysis patients (CREED-1, North Apulian and CREED-2 cohorts; n 783) and in one cohort of stage 25 CKD patients (n 757). We first explored the association between the 17 tag SNPs and all-cause mortality in the CREED-1 cohort and found that patients with the A allele of the FTO rs708259 polymorphism had an elevated risk of mortality (hazard ratio, HR: 1.52, 95 confidence interval (CI) 1.112.08; P 0.008). Similarly, the A allele was associated with an increased risk of death also in the other two dialysis cohorts (North Apulian cohort, risk: 23; CREED-2 cohort, risk: 21). The elevated risk portended by this allele w The A allele of the FTO rs708259 polymorphism is an independent predictor of all-cause mortality in patients with CKD of various severity. These data support our hypothesis that the FTO gene may be a relevant genetic risk factor for mortality in this population.

AB - Polymorphisms in the FTO (fat-mass and obesity-associated) gene have been associated with the body mass index, cancer, type 2 diabetes and hypertension. We investigated the relationship between 17 tag single-nucleotide polymorphisms (SNPs) and all-cause mortality in three cohorts of dialysis patients (CREED-1, North Apulian and CREED-2 cohorts; n 783) and in one cohort of stage 25 CKD patients (n 757). We first explored the association between the 17 tag SNPs and all-cause mortality in the CREED-1 cohort and found that patients with the A allele of the FTO rs708259 polymorphism had an elevated risk of mortality (hazard ratio, HR: 1.52, 95 confidence interval (CI) 1.112.08; P 0.008). Similarly, the A allele was associated with an increased risk of death also in the other two dialysis cohorts (North Apulian cohort, risk: 23; CREED-2 cohort, risk: 21). The elevated risk portended by this allele w The A allele of the FTO rs708259 polymorphism is an independent predictor of all-cause mortality in patients with CKD of various severity. These data support our hypothesis that the FTO gene may be a relevant genetic risk factor for mortality in this population.

U2 - 10.1093/ndt/gfs550

DO - 10.1093/ndt/gfs550

M3 - Article

SN - 0931-0509

VL - 27

SP - iv58-iv62

JO - Nephrology Dialysis Transplantation

JF - Nephrology Dialysis Transplantation

ER -