The gene encoding thioredoxin-interacting protein (TXNIP) is a frequent virus integration site in virus-induced mouse leukemia and is overexpressed in a subset of AML patients

Stefan J. Erkeland, Karishma K. Palande, Marijke Valkhof, Judith Gits, Astrid Danen van Oorschot, Ivo P. Touw*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

21 Citations (Scopus)

Abstract

Thioredoxin-interacting protein (TXNIP) is involved in reactive oxygen species-induced stress responses. In a screen for novel disease genes in murine leukemia virus (MLV)-induced mouse leukemias, we identified Txnip as a frequent target for proviral integration. Ectopic TXNIP expression inhibited the proliferation of myeloid progenitor cells. TXNIP transcript and protein levels were significantly elevated in human AML blasts of certain patients, particularly those harboring translocation t(8;21). Nucleotide sequencing revealed no abnormalities in the TXNIP coding region in AML. These findings suggest that deregulated TXNIP expression contributes to MLV-induced murine leukemia as well as human AML.

Original languageEnglish
Pages (from-to)1367-1371
Number of pages5
JournalLeukemia Research
Volume33
Issue number10
DOIs
Publication statusPublished - Oct 2009

Bibliographical note

© 2009 Elsevier Ltd. All rights reserved.

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