TY - JOUR
T1 - The Generation R Study: design and cohort update 2017
AU - Kooijman, Marjolein
AU - Kruithof, CJ (Claudia)
AU - Duijn, Cornelia
AU - Duijts, Liesbeth
AU - Franco Duran, OH
AU - van IJzendoorn, Marinus
AU - Jongste, Johan
AU - Klaver, Caroline
AU - van der Lugt, Aad
AU - Mackenbach, Johan
AU - Moll, Henriette
AU - Peeters, Robin
AU - Raat, Hein
AU - Rings, Edmond
AU - Rivadeneira, Fernando
AU - van der Schroeff, M.P.
AU - Steegers, Eric
AU - Tiemeier, Henning
AU - Uitterlinden, André
AU - Verhulst, Frank
AU - Wolvius, Eppo
AU - Felix, Janine
AU - Jaddoe, Vincent
PY - 2016
Y1 - 2016
N2 - The Generation R Study is a population-based prospective cohort study from fetal life until adulthood. The study is designed to identify early environmental and genetic causes and causal pathways leading to normal and abnormal growth, development and health from fetal life, childhood and young adulthood. This multidisciplinary study focuses on several health outcomes including behaviour and cognition, body composition, eye development, growth, hearing, heart and vascular development, infectious disease and immunity, oral health and facial growth, respiratory health, allergy and skin disorders of children and their parents. Main exposures of interest include environmental, endocrine, genomic (genetic, epigenetic, microbiome), lifestyle related, nutritional and socio-demographic determinants. In total, 9778 mothers with a delivery date from April 2002 until January 2006 were enrolled in the study. Response at baseline was 61%, and general follow-up rates until the age of 10 years were around 80%. Data collection in children and their parents includes questionnaires, interviews, detailed physical and ultrasound examinations, behavioural observations, lung function, Magnetic Resonance Imaging and biological sampling. Genome and epigenome wide association screens are available. Eventually, results from the Generation R Study contribute to the development of strategies for optimizing health and healthcare for pregnant women and children.
AB - The Generation R Study is a population-based prospective cohort study from fetal life until adulthood. The study is designed to identify early environmental and genetic causes and causal pathways leading to normal and abnormal growth, development and health from fetal life, childhood and young adulthood. This multidisciplinary study focuses on several health outcomes including behaviour and cognition, body composition, eye development, growth, hearing, heart and vascular development, infectious disease and immunity, oral health and facial growth, respiratory health, allergy and skin disorders of children and their parents. Main exposures of interest include environmental, endocrine, genomic (genetic, epigenetic, microbiome), lifestyle related, nutritional and socio-demographic determinants. In total, 9778 mothers with a delivery date from April 2002 until January 2006 were enrolled in the study. Response at baseline was 61%, and general follow-up rates until the age of 10 years were around 80%. Data collection in children and their parents includes questionnaires, interviews, detailed physical and ultrasound examinations, behavioural observations, lung function, Magnetic Resonance Imaging and biological sampling. Genome and epigenome wide association screens are available. Eventually, results from the Generation R Study contribute to the development of strategies for optimizing health and healthcare for pregnant women and children.
U2 - 10.1007/s10654-016-0224-9
DO - 10.1007/s10654-016-0224-9
M3 - Article
SN - 0393-2990
VL - 31
SP - 1243
EP - 1264
JO - European Journal of Epidemiology
JF - European Journal of Epidemiology
IS - 12
ER -
