The Gut Microbiome: a New Frontier in Musculoskeletal Research

R. Li, C. G. Boer, L. Oei, Carolina Medina-Gomez*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

19 Citations (Scopus)
31 Downloads (Pure)


Purpose of the review: The human gut harbors a complex community of microbes that influence many processes regulating musculoskeletal development and homeostasis. This review gives an update on the current knowledge surrounding the impact of the gut microbiota on musculoskeletal health, with an emphasis on research conducted over the last three years. 

Recent findings: The gut microbiota and their metabolites are associated with sarcopenia, osteoporosis, osteoarthritis, and rheumatoid arthritis. The field is moving fast from describing simple correlations to pursue establishing causation through clinical trials. 

Summary: The gut microbiota and their microbial-synthesized metabolites hold promise for offering new potential alternatives for the prevention and treatment of musculoskeletal diseases given its malleability and response to environmental stimuli.

Original languageEnglish
Pages (from-to)347-357
Number of pages11
JournalCurrent Osteoporosis Reports
Issue number3
Early online date17 Apr 2021
Publication statusPublished - Jun 2021

Bibliographical note

Funding Information:
R.L is supported by the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 860898 [FIDELIO]. L.O. is funded by an Erasmus MC fellowship grant.

Publisher Copyright:
© 2021, The Author(s).


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